LRP5 gene

Known as: VBCH2, OPTA1, Low Density Lipoprotein Receptor-Related Protein 5 Gene 
This gene is involved in endocytosis and signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
02040608019752017

Papers overview

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Highly Cited
2011
Highly Cited
2011
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5… (More)
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Highly Cited
2006
Highly Cited
2006
UNLABELLED We compared and contrasted the mechanism of action for the cysteine knot protein subfamily, Wise and Sost (Sclerostin… (More)
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Highly Cited
2006
Highly Cited
2006
The cell surface receptor, low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass. Loss-of… (More)
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Highly Cited
2005
Highly Cited
2005
The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found… (More)
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Highly Cited
2004
Highly Cited
2004
Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Autosomal dominant… (More)
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Highly Cited
2003
Highly Cited
2003
A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice expressing this LRP5 mutation have a similar… (More)
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Highly Cited
2003
Highly Cited
2003
Bone is a dynamic tissue that is subject to the balanced processes of bone formation and bone resorption. Imbalance can give rise… (More)
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Highly Cited
2003
Highly Cited
2003
A Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) plays an essential role in bone accrual and eye… (More)
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Highly Cited
2003
Highly Cited
2003
UNLABELLED Wnt/beta-catenin signaling has recently been suggested to be involved in bone biology. The precise role of this… (More)
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Highly Cited
2001
Highly Cited
2001
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density… (More)
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