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Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
TLDR
Evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine‐ and stress‐induced apoptosis. Expand
A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia.
TLDR
It is shown that signal transducers of transforming growth factor beta superfamily receptors, Smads, interact with RUNX2 in vivo and in vitro and enhance the transactivation ability of this factor. Expand
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.
TLDR
Osteoblast differentiation induced by BMPs is thus mediated mainly via the Smad-signaling pathway, whereas chondrogenic differentiation may be transmitted by Smad -dependent and independent pathways. Expand
Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction.
TLDR
It is shown that among members of the BMP family, BMP-4 and growth/differentiation factor 5 (GDF-5) induce osteoblast differentiation through the activation of three receptor-regulated Smads (i.e. Smad1, Smad5 and Smad8). Expand
Epithelial to Mesenchymal Transition in an Epidermal Growth Factor Receptor-Mutant Lung Cancer Cell Line with Acquired Resistance to Erlotinib
TLDR
The results indicate that it would be important to consider the influence of EMT in the development of treatments against acquired resistance to gefitinib or erlotinib in the treatment of non-small cell lung cancer with EGFR mutations. Expand
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice.
TLDR
Exogenous Smad7 introduced by a recombinant human type 5 adenovirus vector prevented bleomycin-induced lung fibrosis in mice, suggesting that Smad 7 may have applicability in the treatment of pulmonary fibrosis. Expand
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor‐β in human umbilical vein endothelial cells
TLDR
Microarray analysis of human umbilical vein endothelial cells infected with recombinant adenoviruses carrying a constitutively active form of ALK‐1 or AlK‐5 revealed some new targets of TGF‐β in endothelial Cells, and differences in transcriptional regulation patterns between ALK •1 and ALK•5. Expand
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.
TLDR
Inhibition of Smad3 might decrease tissue damage and reduce fibrosis after exposure to ionizing irradiation, as did mice exposed to whole-body irradiation. Expand
LATS2 is a tumor suppressor gene of malignant mesothelioma.
TLDR
The data indicate that Hippo pathway dysregulation is frequent in MM cells with inactivation of LATS2 or an upstream regulator of this pathway, Merlin, which is encoded by NF2. Expand
Amelioration of Radiation-induced Fibrosis
TLDR
Halofuginone blocked TGF-β-induced delocalization of tight junction ZO-1, a marker of epidermal mesenchymal transition, in NMuMg mammary epithelial cells and suggest halofug inone may have in vivo anti-fibrogenesis characteristics. Expand
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