LMX1B gene

Known as: LIM Homeobox Transcription Factor 1, Beta Gene, LIM HOMEOBOX TRANSCRIPTION FACTOR 1, BETA, LMX1B 
This gene plays a role in both transcriptional regulation and the mediation of limb development.
National Institutes of Health

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Cell Differentiation processHomo sapiensLIM homeobox transcription factor 1 betaLimb Development
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LMX1B wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
LIM homeodomain transcription factors, Lmx1a and Lmx1b, are required for the development of midbrain dopaminergic (mDA) neurons… (More)
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Highly Cited
2003
Highly Cited
2003
Lmx1b is essential for the development of serotonergic neurons
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic… (More)
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Highly Cited
2002
Highly Cited
2002
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.
Patients with nail-patella syndrome often suffer from a nephropathy, which ultimately results in chronic renal failure. The… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation.
LMX1B encodes a LIM-homeodomain transcription factor. Mutations in LMX1B cause nail-patella syndrome (NPS), an autosomal dominant… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome
Basement membrane (BM) morphogenesis is critical for normal kidney function. Heterotrimeric type IV collagen, composed of… (More)
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Highly Cited
2000
Highly Cited
2000
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
We identified the LIM homeodomain transcription factor Lmx1b in the mesencephalic dopamine (mesDA) systems of embryos and adults… (More)
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Highly Cited
2000
Highly Cited
2000
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer.
Cells in the caudal mesencephalon and rostral metencephalon become organized by signals emanating from the isthmus organizer (IsO… (More)
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Highly Cited
1998
Highly Cited
1998
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed… (More)
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Highly Cited
1998
Highly Cited
1998
Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome
The LIM-homeodomain protein Lmxlb plays a central role in dorso-ventral patterning of the vertebrate limb1. Targeted disruption… (More)
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1998
1998
Mutation analysis of LMX1B gene in nail-patella syndrome patients.
Nail-patella syndrome (NPS), a pleiotropic disorder exhibiting autosomal dominant inheritance, has been studied for >100 years… (More)
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