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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
TLDR
It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments.
TLDR
Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and it is shown that early scleraxis expression marks the progenitor cell populations for these tissues.
Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.
TLDR
It is demonstrated that Spitz triggers the DER signaling cascade, a subset of developmental processes that are similar to those regulated by DER, the Drosophila EGF receptor homolog, and graded activation of this pathway may normally give rise to a repertoire of discrete cell fates in the ventral ectoderm.
Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
TLDR
The phenotype of Scx-/- mutants emphasizes the diversity of tendon tissues and represents the first molecular insight into the important process of tendon differentiation.
Recruitment and maintenance of tendon progenitors by TGFβ signaling are essential for tendon formation
TLDR
TGFβ signaling is essential for maintenance of TNPs, and it is proposed that it also mediates the recruitment of new tendon cells by differentiating muscles and cartilage to establish the connections between tendon primordia and their respective musculoskeletal counterparts, leading to the formation of an interconnected and functionally integrated musculOSkeletal system.
Inhibition of Drosophila EGF receptor activation by the secreted protein Argos
TLDR
It is shown that Argos does indeed repress this pathway in vivo and find that, in vitro, Argos protein can inhibit the activation of DER by Spitz, which is the first in vivo example of an extracellular inhibitor of a receptor tyrosine kinase.
Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.
TLDR
It is shown that argos expression in the ventral ectoderm is induced by the DER pathway, which may represent a general paradigm for signaling pathways inducing diverse cell fates within a population of non-committed cells.
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