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Limb Development

Interdependent positional signaling by the apical ectodermal ridge, the posterior mesenchyme zone of polarizing activity, and the non ridge ectoderm… 
National Institutes of Health

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ALX4 geneALX4 wt AlleleBiologic DevelopmentCD44 protein, human

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limb morphogenesisnail development

Papers overview

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Review
2006
Review
2006
The control of chondrogenesis
Chondrogenesis is the earliest phase of skeletal development, involving mesenchymal cell recruitment and migration, condensation… 
Highly Cited
2006
Highly Cited
2006
Isl1Cre reveals a common Bmp pathway in heart and limb development
A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have… 
Highly Cited
2003
Highly Cited
2003
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a… 
Highly Cited
1999
Highly Cited
1999
Fgf10 is essential for limb and lung formation
The interactions between fibroblast growth factors (FGF) and their receptors have important roles in mediating mesenchymal… 
Highly Cited
1999
Highly Cited
1999
Conserved regulation of proximodistal limb axis development by Meis1/Hth
Vertebrate limbs grow out from the flanks of embryos, with their main axis extending proximodistally from the trunk. Distinct… 
Review
1997
Review
1997
Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens.
Highly Cited
1996
Highly Cited
1996
The mouse Engrailed-1 gene and ventral limb patterning
DURING vertebrate limb development, positional information must be specified along three distinct axes. Although much progress… 
Highly Cited
1996
Highly Cited
1996
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
Sonic hedgehog is a secreted factor regulating patterning of the anterior-posterior axis in the developing limb. The signaling… 
Highly Cited
1994
Highly Cited
1994
FGF-2: apical ectodermal ridge growth signal for chick limb development.
The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene… 
Highly Cited
1994
Highly Cited
1994
Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.
We show here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb. During early stages… 
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