Skip to search formSkip to main contentSkip to account menu

LLGL1 wt Allele

Known as: LLGL, HUGL, HUGL1 
Human LLGL1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 19 kb in length. This allele, which encodes lethal(2) giant… 
National Institutes of Health

Related topics

Related topics

9 relations
17p11.2Cell MovementCytokinesisCytoskeletal Modeling

Broader (1)

LLGL1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features
Marfanoid habitus (MH) combined with intellectual disability (ID) is a genetically and clinically heterogeneous group of… 
Highly Cited
2017
Highly Cited
2017
Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a… 
2015
2015
Hugl-1 inhibits glioma cell growth in intracranial model
Drosophila lethal (2) giant larvae (lgl) has been reported as a tumor suppressor and could regulate the Drosophila hippo… 
2013
2013
Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels
Opioid drugs are highly addictive and their abuse has a strong genetic load. Dopamine–glutamate interactions are hypothesized to… 
Highly Cited
2009
Highly Cited
2009
Aberrant Splicing of Hugl-1 Is Associated with Hepatocellular Carcinoma Progression
Purpose: Lethal giant larvae functions as a cell polarity regulator and a tumor suppressor in Drosophila. Its evolutionary… 
2008
2008
Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.
2007
2007
Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans.
A two-stage association study was conducted targeting a genomic region on chromosome 17p13 that we reported likely to harbor… 
Highly Cited
2006
Highly Cited
2006
Expression of Hugl-1 is strongly reduced in malignant melanoma
The human gene Hugl-1 (Llgl/Lgl1) has significant homology to the Drosophila tumor suppressor gene lethal(2)giant larvae (lgl… 
Highly Cited
2005
Highly Cited
2005
Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
The human gene, human giant larvae (Hugl-1/Llg1/Lgl1) has significant homology to the Drosophila tumour suppressor gene lethal(2… 
Highly Cited
1995
Highly Cited
1995
A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.
Inactivation of the tumour suppressor gene lethal(2) giant larvae (D-lgl) of Drosophila leads to malignant transformation of the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)