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Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
BACKGROUND While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are patients requiring other treatments. DeepExpand
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Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the potential of OTExpand
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Oxytocin facilitates protective responses to aversive social stimuli in males
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may reduce that of negative ones by inhibiting amygdala activation, although it is unclear whether the latter causesExpand
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Ambiguous-Cue Interpretation is Biased Under Stress- and Depression-Like States in Rats
Negative cognitive bias—the tendency to interpret ambiguous situations pessimistically—is a central feature of stress-related disorders such as depression. The underlying neurobiology of this bias,Expand
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An emotion-induced retrograde amnesia in humans is amygdala- and β-adrenergic-dependent
The influence of emotion on human memory is associated with two contradictory effects in the form of either emotion-induced enhancements or decrements in memory. In a series of experiments involvingExpand
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Noradrenergic Modulation of Emotion-Induced Forgetting and Remembering
We used a free-recall paradigm to establish a behavioral index of the retrograde and anterograde interference of emotion with episodic memory encoding. In two experiments involving 78 subjects, weExpand
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Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modalityExpand
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Oxytocin enhances brain reward system responses in men viewing the face of their female partner
Significance Sexual monogamy is potentially costly for males, and few mammalian species along with humans exhibit it. The hypothalamic peptide oxytocin (OXT) has been implicated in mediating pairExpand
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Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
There has been unprecedented interest in the prosocial effects of the neuropeptide oxytocin in humans over the last decade. A range of studies has demonstrated correlations between basal oxytocinExpand
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Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state.
BACKGROUND Verbal learning and memory deficits are frequent among patients with schizophrenia and correlate with reduced magnetic resonance imaging (MRI) volumes of the hippocampus in these patients.Expand
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