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LEUKOCYTE ADHESION DEFICIENCY

Known as: adhesion deficiencies leukocyte, adhesions deficiency leukocyte, leucocyte adhesion deficiency 
A rare autosomal recessive immunodeficiency disorder caused by deficiency of CD18 expression. It is characterized by defects in neutrophil adhesion… 
National Institutes of Health

Related topics

Related topics

3 relations
ITGB2 geneITGB2 wt AlleleITGB2, IVS4AS, 169-BP DEL, -37

Papers overview

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Highly Cited
2011
Highly Cited
2011
A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion
Leukocyte adhesion deficiency type III is a recently described condition involving a Glanzmann-type bleeding syndrome and… 
Review
2009
Review
2009
The Kindlin protein family: new members to the club of focal adhesion proteins.
Highly Cited
2007
Highly Cited
2007
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.
Single gene mutations in beta integrins can account for functional defects of individual cells of the hematopoietic system. In… 
Review
2002
Review
2002
Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.
Leukocyte adhesion deficiency (LAD) syndromes are failures of innate host defenses against bacteria, fungi, and other… 
Review
1999
Review
1999
Of man and mouse: leukocyte and endothelial adhesion molecule deficiencies.
“It is in her moments of abnormalities that nature reveals its secrets.” (Goethe) I MPORTANT INSIGHTS into a number of… 
Highly Cited
1993
Highly Cited
1993
In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes.
The selectins and the beta 2-integrins (CD11/CD18) mediate distinct adhesive interactions between neutrophils and endothelial… 
Highly Cited
1992
Highly Cited
1992
Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle.
Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion… 
Highly Cited
1992
Highly Cited
1992
Leukocyte adhesion deficiency: clinical and postmortem observations.
The clinical and autopsy findings in a patient with the severe form of leukocyte adhesion deficiency are presented. An 18-month… 
Highly Cited
1991
Highly Cited
1991
A form of circulating ICAM-1 in human serum.
A circulating form of the usually membrane-bound intercellular adhesion molecule-1 (ICAM-1) was identified and characterized in… 
Review
1988
Review
1988
Leukocyte adhesion deficiency: molecular basis and functional consequences.
Leukocyte adhesion deficiency disease is characterized by a mutation in the gene encoding the beta-subunit shared by three… 
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