• Publications
  • Influence
Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.
TLDR
Results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophil to IC AM-1 by a Mac-2-dependent process. Expand
Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.
TLDR
It is demonstrated that attachment and transendothelial migration of PMN in vitro depend substantially on both CD18 on the PMN and ICAM-1 on the endothelial cell. Expand
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.
TLDR
Its expression by cells and tissues not normally exposed to pancreatic trypsin suggests that other proteases could serve as physiological activators and PAR-2 may serve as aTrypsin sensor in the gut. Expand
Heterogeneity of expression of E- and P-selectins in vivo.
TLDR
It is suggested that P-selectin is constitutively expressed on vascular endothelium in some tissues of the mouse and that there are significant regional differences in the magnitude and time course of histamine- and endotoxin-induced P- selectin expression. Expand
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TLDR
Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense. Expand
SEX‐HORMONE‐BINDING GLOBULIN
  • D. Anderson
  • Biology, Medicine
  • Clinical endocrinology
  • 1 January 1974
TLDR
By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed, and the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease. Expand
The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features.
TLDR
In vivo abnormalities of leukocyte mobilization reflect the critical roles of Mac-1 glycoproteins in adhesive events required for endothelial margination and tissue exudation as well as complement- or antibody-dependent cytotoxicity. Expand
Regional differences in constitutive and induced ICAM-1 expression in vivo.
TLDR
It is indicated that ICAM-1 is constitutively expressed on vascular endothelium in all organs of the rat and that there are significant regional differences in the magnitude and time course of endotoxin-induced ICAM -1 expression. Expand
Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.
TLDR
These studies indicate that while there are significant quantitative differences in constitutive and induced expression of murine ICAM-1 and VCam-1, the kinetics and dose-response characteristics of the two adhesion molecules to TNF-alpha are qualitatively similar. Expand
Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils.
TLDR
It is indicated that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors. Expand
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