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ITGB2 gene

Known as: LEUKOCYTE-ASSOCIATED ANTIGENS CD18/11A, CD18/11B, CD18/11C, CD18, complement component 3 receptor 3 and 4 subunit 
This gene is involved in the mediation of cellular adhesion and cell-surface signal transduction.
National Institutes of Health

Related topics

Related topics

11 relations
CD18 AntigensCell AdhesionCell-Cell Adhesion ProcessITGAL gene

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ITGB2 wt Allele

Papers overview

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Review
2018
Review
2018
Evaluation of ITGB2 (CD18) and SELL (CD62L) genes expression and methylation of ITGB2 promoter region in patients with systemic sclerosis
Systemic sclerosis (SSc), an autoimmune disease of connective tissue, is characterized by inflammation, fibrosis, and vessel… 
2018
2018
[Novel mutations of ITGB2 induced leukocyte adhesion defect type 1].
Objective: To investigate the pathogenic mechanism of two novel ITGB2 mutations in leukocyte adhesion defect type 1 (LAD1… 
2018
2018
Detection of leukocyte adhesion deficiency type 1 in an infant by high-throughput targeted exome sequencing
Leukocyte adhesion deficiency type 1 (LAD-I) characterized by immune-deficiency and leukocytosis is rare in infant patients. A 43… 
2014
2014
Prenatal diagnosis of leukocyte adhesion deficiency type-1 (five cases from iran with two new mutations).
Leukocyte adhesion deficiency type-1(LAD-1) is one of the immunodeficiency autosomal recessive diseases that results from… 
2010
2010
A novel point mutation in CD18 causing leukocyte adhesion deficiency in a Chinese patient.
BACKGROUND Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, autosomal recessive inherited immunodeficiency disease… 
2006
2006
Cloning and comparison of bighorn sheep CD18 with that of domestic sheep, goats, cattle, humans and mice.
2006
2006
Analysis of mutations in the ITGB2 gene in goats using PCR-RFLP and DNA sequencing
2000
2000
Design and synthesis of germline-based hemi-humanized single-chain Fv against the CD18 surface antigen.
The 6.7 murine monoclonal antibody (mAb) recognizes the human CD18 antigen and is therefore of interest as an anti-inflammatory… 
1993
1993
Effect of activation on adhesion of flowing neutrophils to cultured endothelium: time course and inhibition by a calcium channel blocker (nitrendipine)
1 Adhesion of neutrophils to vascular endothelium plays an important role in inflammation and thrombosis. Modulation of adhesion… 
1981
1981
Structural homology of the major internal proteins of endogeneous type C viruses of two distantly related species of Old World monkeys: Macaca arctoides and Colobus polykomos.
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