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LCK gene

Known as: Lymphocyte-Specific Protein Tyrosine Kinase Gene, Oncogene LCK, LCK proto-oncogene, Src family tyrosine kinase 
Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain… 
National Institutes of Health

Related topics

Related topics

13 relations
B-Cell ActivationCell Differentiation processCell ProliferationHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
Leukocyte common antigen-related molecule (LAR) is a receptor-like protein tyrosine phosphatase (PTPase) with two PTPase domains… 
1998
1998
Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes.
By using antisense RNA, Lck-deficient transfectants of a T helper 2 (Th2) clone have been derived and shown to have a qualitative… 
1997
1997
Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development
The developmental stages and the role of protein tyrosine kinases (PTK) in the maturation of CD3+CD8αα+ intraepithelial… 
Highly Cited
1996
Highly Cited
1996
Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK (*)
Activation of CD28 on T lymphocytes initiates a cascade of intracellular events, which in concert with activation of the T cell… 
1996
1996
CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK.
Ligation of the CD2 cell surface glycoprotein expressed on T lymphocytes and NK cells induces protein tyrosine phosphorylation… 
1993
1993
Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.
As presently reported, both ionizing radiation and engagement of the CD19 receptor are capable of inducing apoptosis in B-lineage… 
1992
1992
Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases…
We have previously reported the establishment of an interleukin-3 (IL-3)-dependent and phenotypically myeloid cell line (TALL-103… 
1991
1991
The LCK Gene Is Involved in the t(1;7)(p34;q34) in the T‐Cell Acute Lymphoblastic Leukemia Derived Cell Line, HSB‐2
HSB‐2 is a cell line derived from a patient who had T‐cell acute lymphoblastic leukemia (T‐cell ALL) with a t( 1;7)(p34;q34). We… 
Highly Cited
1990
Highly Cited
1990
Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm).
Highly Cited
1986
Highly Cited
1986
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.
The murine lck gene is closely related to a family of cellular protooncogenes and encodes a lymphocyte-specific, membrane… 
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