LCK gene

Known as: Lymphocyte-Specific Protein Tyrosine Kinase Gene, Oncogene LCK, LCK proto-oncogene, Src family tyrosine kinase 
Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
We aimed to identify peripheral blood mononuclear cell (PBMC) gene expression profiles predictive of poor outcomes in idiopathic… (More)
  • figure 1
  • figure 2
  • table 3
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Although remission rates for metastatic melanoma are generally very poor, some patients can survive for prolonged periods… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
2008
2008
Sorafenib, a novel drug for metastatic renal cancer, has broad-spectrum activity against multiple tyrosine kinases, including Raf… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor-mediated signal transduction… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
LCK is a non-receptor protein tyrosine kinase required for signal transduction via the T-cell antigen receptor (TCR). LCK N… (More)
  • table I
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
1996
1996
Functional T lymphocyte activation requires concurrent stimulation of the TCR complex and an accessory molecule, most frequently… (More)
Is this relevant?
1994
1994
The tyrosine protein kinase p56lck transduces signals important for antigen-induced T-cell activation. In transgenic mice, p56lck… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
THE protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases1–3. It is… (More)
Is this relevant?
1991
1991
A case of T lymphoblastic leukemia (T-ALL) showing t(1;7)(p34;q34) as the sole karyotypic abnormality was investigated at the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?