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LATS1 protein, human

Known as: LATS Homolog 1, LATS, large tumor suppressor, homolog 1 (Drosophila) protein, human, LATS1 Protein 
Serine/threonine-protein kinase LATS1 (1130 aa, ~127 kDa) is encoded by the human LATS1 gene. This protein plays a role in both mitosis and serine… 
National Institutes of Health

Related topics

Related topics

13 relations
Cell Cycle ControlEnzyme GeneHomo sapiensLATS1 gene

Broader (1)

Protein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1
BackgroundHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and tumor recurrence and metastasis… 
Highly Cited
2014
Highly Cited
2014
Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling
Highly Cited
2009
Highly Cited
2009
Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma.
Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. Epigenetic… 
Highly Cited
2007
Highly Cited
2007
RASSF1A Is Part of a Complex Similar to the Drosophila Hippo/Salvador/Lats Tumor-Suppressor Network
Highly Cited
2006
Highly Cited
2006
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
Highly Cited
2006
Highly Cited
2006
The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.
Highly Cited
2005
Highly Cited
2005
Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers
Purpose: LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the… 
Highly Cited
2004
Highly Cited
2004
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show… 
Highly Cited
2001
Highly Cited
2001
Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
The lats gene encodes a family of proteins conserved from insects to humans. Drosophila carrying lats mutant cells or mice… 
Highly Cited
1999
Highly Cited
1999
A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
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