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LAT gene

Known as: LINKER FOR ACTIVATION OF T CELLS, LAT1, linker for activation of T cells, transmembrane adaptor 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution.
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we… Expand
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Highly Cited
2010
Highly Cited
2010
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
The organization and dynamics of receptors and other molecules in the plasma membrane are not well understood. Here we analyzed… Expand
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Highly Cited
2010
Highly Cited
2010
Palmitoylation regulates raft affinity for the majority of integral raft proteins
The physical basis for protein partitioning into lipid rafts remains an outstanding question in membrane biology that has… Expand
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Highly Cited
2008
Highly Cited
2008
Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells1
Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (LatY136F mice… Expand
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Highly Cited
2008
Highly Cited
2008
Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation
Nutrient transporters and ABC efflux pumps at the blood-brain barrier are major determinants of drug penetration into the brain… Expand
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Highly Cited
2005
Highly Cited
2005
Identification of LAT4, a Novel Amino Acid Transporter with System L Activity*
System L amino acid transporters mediate the movement of bulky neutral amino acids across cell membranes. Until now three… Expand
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Highly Cited
2003
Highly Cited
2003
LAB: A new membrane-associated adaptor molecule in B cell activation
The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar… Expand
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Highly Cited
2002
Highly Cited
2002
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
FcεRI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex… Expand
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Highly Cited
2001
Highly Cited
2001
Polyunsaturated Eicosapentaenoic Acid Displaces Proteins from Membrane Rafts by Altering Raft Lipid Composition*
Polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (20:5 (n-3)) inhibit T lymphocyte activation probably by… Expand
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Highly Cited
1998
Highly Cited
1998
Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)*
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid… Expand
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