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LAT gene

Known as: LINKER FOR ACTIVATION OF T CELLS, LAT1, linker for activation of T cells, transmembrane adaptor 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
Summary: Signals emanating from antigen receptors critically regulate immune cell activation, survival, and differentiation… 
Highly Cited
2005
Highly Cited
2005
Cutting Edge: Localization of Linker for Activation of T Cells to Lipid Rafts Is Not Essential in T Cell Activation and Development1
It has been proposed that upon T cell activation, linker for activation of T cells (LAT), a transmembrane adaptor protein… 
Review
2005
Review
2005
NTAL/LAB and LAT: a balancing act in mast-cell activation and function.
Highly Cited
2004
Highly Cited
2004
Involvement of filamentous actin in setting the threshold for degranulation in mast cells
Previous studies using cytochalasins and latrunculin B, inhibitors of actin polymerization, showed that filamentous (F)‐actin had… 
Review
2003
Review
2003
Transmembrane adapters: attractants for cytoplasmic effectors
Transmembrane adapter proteins (TRAPs) are a relatively new and growing family of proteins that include linker for activation of… 
2001
2001
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains.
Highly Cited
2000
Highly Cited
2000
Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling
Initiation of T cell antigen receptor (TCR) signaling is dependent on Lck, a Src family kinase. The Src-like adaptor protein… 
2000
2000
A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cells by IgE-antigen complex triggers signal transduction… 
Highly Cited
2000
Highly Cited
2000
The Src Homology 2 Domain of Vav Is Required for Its Compartmentation to the Plasma Membrane and Activation of C-Jun Nh2-Terminal Kinase 1
Vav is a hematopoietic cell–specific guanine nucleotide exchange factor (GEF) whose activation is mediated by receptor engagement… 
Highly Cited
2000
Highly Cited
2000
Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane
B cell linker protein (BLNK) and Src homology 2 domain–containing leukocyte protein of 76 kD (SLP-76) are adaptor proteins… 
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