FAQ

LAT gene

Known as: LINKER FOR ACTIVATION OF T CELLS, LAT1, linker for activation of T cells, transmembrane adaptor 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
0102019912017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution.
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we… (More)
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Highly Cited
2010
Highly Cited
2010
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
The organization and dynamics of receptors and other molecules in the plasma membrane are not well understood. Here we analyzed… (More)
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Highly Cited
2010
Highly Cited
2010
Palmitoylation regulates raft affinity for the majority of integral raft proteins.
The physical basis for protein partitioning into lipid rafts remains an outstanding question in membrane biology that has… (More)
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2006
2006
LAT-mediated signaling in CD4+CD25+ regulatory T cell development
Engagement of the T cell receptor for antigen (TCR) induces formation of signaling complexes mediated through the transmembrane… (More)
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2005
2005
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow.
The roles of the 2 major platelet-collagen receptors, glycoprotein VI (GPVI) and integrin alpha2beta1, have been intensely… (More)
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2005
2005
Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cells.
Some transmembrane proteins must associate with lipid rafts to function. However, even if acylated, transmembrane proteins should… (More)
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Highly Cited
2001
Highly Cited
2001
Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition.
Polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (20:5 (n-3)) inhibit T lymphocyte activation probably by… (More)
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Highly Cited
2001
Highly Cited
2001
High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT
In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of… (More)
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2001
2001
Identification of the minimal tyrosine residues required for linker for activation of T cell function.
The linker for activation of T cells (LAT) is essential for signaling through the T cell receptor (TCR). Following TCR… (More)
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Highly Cited
2000
Highly Cited
2000
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated… (More)
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