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LACTASE PERSISTENCE

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA
The genetic adaptation of humans to the consumption of milk from dairying animals is one of the most emblematic cases of recent… 
Highly Cited
2016
Highly Cited
2016
Food and pathogen adaptations in the Angolan Namib desert: Tracing the spread of lactase persistence and human African trypanosomiasis resistance into southwestern Africa.
OBJECTIVES We investigated the frequency distribution and haplotype diversity of human African trypanosomiasis (HAT) resistance… 
Highly Cited
2014
Highly Cited
2014
Tracing Pastoralist Migrations to Southern Africa with Lactase Persistence Alleles
Highly Cited
2014
Highly Cited
2014
Lactase Persistence Alleles Reveal Partial East African Ancestry of Southern African Khoe Pastoralists
Highly Cited
2014
Highly Cited
2014
Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe.
Lactase persistence (LP) is a genetically determined trait whereby the enzyme lactase is expressed throughout adult life. Lactase… 
Review
2012
Review
2012
Association of the European Lactase Persistence Variant (LCT-13910 C>T Polymorphism) with Obesity in the Canary Islands
Background European lactose tolerance genotype (LCT -13910 C>T, rs4988234) has been positively associated to body mass indexes… 
2012
2012
Several Different Lactase Persistence Associated Alleles and High Diversity of the Lactase Gene in the Admixed Brazilian Population
Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The −13910 C>T polymorphism, located 14 Kb… 
Highly Cited
2009
Highly Cited
2009
The Origins of Lactase Persistence in Europe
Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and… 
Highly Cited
2008
Highly Cited
2008
Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture.
Highly Cited
2007
Highly Cited
2007
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
A single-nucleotide variant, C/T(-13910), located 14 kb upstream of the lactase gene (LCT), has been shown to be completely… 
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