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L 733060

Known as: L 733,060, L-733,060, L-733060 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts.
Osteosarcoma is a highly malignant bone tumor in children and adolescents. Aprepitant is a selective high‑affinity antagonist of… 
2012
2012
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines
SummarySubstance P and neurokinin-1 (NK-1) receptor antagonists respectively induce cell proliferation and cell inhibition in… 
Highly Cited
2009
Highly Cited
2009
Catalytic asymmetric synthesis of piperidines from pyrrolidine: concise synthesis of L-733,060.
Catalytic asymmetric deprotonation-aldehyde trapping-ring expansion from a 5- to a 6-ring delivers a concise route to each… 
2008
2008
TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.
This study was designed to test the hypothesis that the transient receptor potential vanilloid type 1 (TRPV1) channel, expressed… 
2006
2006
A new chronic itch model accompanied by skin lesions in hairless mice.
2005
2005
G-Protein Activation by Neurokinin-1 Receptors Is Dynamically Regulated during Persistent Nociception
Previous work has demonstrated that persistent nociception evokes increased neurokinin-1 receptor (NK-1) gene expression in the… 
2004
2004
Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor-α-Mediated Apoptotic Liver Damage
Previously, we have shown that primary afferent neurons are necessary for disease activity in immune-mediated liver injury in… 
2004
2004
Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines.
We have performed an in vitro study of the growth-inhibitory capacity of the potent and long-acting NK1 receptor antagonist L-733… 
2002
2002
Neurokinin‐1 (NK‐1) receptor antagonists abrogate methamphetamine‐induced striatal dopaminergic neurotoxicity in the murine brain
Methamphetamine (METH) is an addictive substance that also causes extensive neural degeneration in the central nervous system… 
2001
2001
Substance P Modulates Cocaine‐Evoked Dopamine Overflow in the Striatum of the Rat Brain
Abstract: To study the role of the neuropeptide substance P in modulating some of the effects of cocaine in the striatum, we… 
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