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A T cell-dependent experimental liver injury in mice inducible by concanavalin A.
Male NMRI or BALB/c mice developed severe liver injury as assessed by transaminase release within 8 h when an intravenous dose greater than 1.5 mg/kg concanavalin A (Con A) was given.Expand
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.
We investigated the role of hepatocyte apoptosis in four different murine models of acute inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by endotoxin infectionExpand
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A.
BACKGROUND & AIMS T cell-dependent liver injury involving endogenous tumor necrosis factor (TNF) alpha can be induced by either concanavalin A in naive mice or by activating anti-CD3 antibody orExpand
Concanavalin A—induced T‐cell—mediated hepatic injury in mice: The role of tumor necrosis factor
Concanavalin A activates T lymphocytes in vitro and causes T‐cell‐dependent hepatic injury in mice. T lymphocytes were previously identified as effector cells of concanavalin A‐induced liver injury.Expand
Immune tolerance: what is unique about the liver.
The 'liver tolerance effect' mediates local and systemic tolerance to self and foreign antigens and has been attributed to specialized resident cells expressing anti-inflammatory mediators andExpand
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest.
Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity. However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had been pretreated withExpand
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis
The significance of tumor necrosis factor receptor 1 (TNFR1) for TNF function in vivo is well documented, whereas the role of TNFR2 so far remains obscure. In a model of concanavalin A (ConExpand
Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells.
NKT cells expressing phenotypic markers of both T and NK cells seem to be pivotal in murine models of immune-mediated liver injury, e.g., in Con A-induced hepatitis. Also alpha-galactosylceramideExpand
Cytokine expression in three mouse models of experimental hepatitis.
The activation of T-cells and macrophages and subsequent induction of cytokines are critical factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, e.g. TNF has beenExpand
Importance of Kupffer cells for T-cell-dependent liver injury in mice.
T cells seem to be responsible for liver damage in any type of acute hepatitis. Nevertheless, the importance of Kupffer cells (KCs) for T-cell-dependent liver failure is unclear. Here we focus on theExpand