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TRPV1 Gene Knockout Impairs Postischemic Recovery in Isolated Perfused Heart in Mice
The data indicate that TRPV1 plays a role in protecting the heart from injury possibly via increasing SP release and that deletion of this receptor reconditions the heart for escaping, at least in part, from injurypossibly via enhancing NK1 receptor function.
N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.
OLDA exerts a cardiac protective effect during I/R injury in WT hearts via CGRP and SP release, which is abolished by PKC or K(+) channel antagonists.
Anandamide-Induced Depressor Effect in Spontaneously Hypertensive Rats: Role of the Vanilloid Receptor
Data indicate that in addition to activation of cannabinoid type 1, anandamide may serve as an endogenous compound to stimulate VR1, leading to a decrease in blood pressure via CGRP release from sensory nerve terminals.
The vanilloid receptor and hypertension
- Donna H. Wang
- BiologyActa Pharmacologica Sinica
- 1 March 2005
Data indicate that sensory nerves counterbalance the prohypertensive effects of several neurohormonal systems to maintain normal blood pressure when challenged with salt loading, and the therapeutic utilities of vanilloid compounds, endogenous agonists, and sensory neuropeptides are also discussed.
TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.
PC-induced protection of the heart was impaired in TRPV1(-/-) hearts, indicating that TRPv1 contributes to the beneficial effects of preconditioning against I/R injury through release substance P and CGRP.
VR1-Mediated Depressor Effects During High-Salt Intake: Role of Anandamide
Data show that HS upregulates mesenteric VR1 expression, HS increases sensitivity of blood pressure to AEA, and HS-induced enhancement of the depressor effect of AEA can be prevented only when both VR1 and CB1 receptors are blocked.
Angiotensin II inhibits [Formula: see text]absorption via a cytochrome P-450-dependent pathway in MTAL.
It is demonstrated that ANG II inhibits absorption in the MTAL via a cytochrome P-450-dependent signaling pathway, most likely involving the production of 20-HETE, and may play a key role in the ability of the kidney to regulate sodium balance and extracellular fluid volume independently of acid-base balance.
TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides
TRPV1 mediates glucose-induced insulin secretion likely through CGRP and SP release, and was attenuated by AMG9810, C GRP8-37, or RP67580 in WT mice.
The effects of celiac ganglionectomy on sympathetic innervation to the splanchnic organs in the rat
Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant.
Interestingly, when expressed in the COS-7 epithelial cell line, TRPV1(VAR) functioned in a dominant-negative acting capacity, partially blocking TRPv1-dependent resiniferatoxin responsiveness.