Kinome

The set of all kinases expressed in a cell or contained in a genome.
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth… (More)
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2016
2016
Small-molecule BET bromodomain inhibitors (BETis) are actively being pursued in clinical trials for the treatment of a variety of… (More)
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Highly Cited
2015
Highly Cited
2015
Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but resistance frequently develops… (More)
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Highly Cited
2014
Highly Cited
2014
or even impossible to be captured by cellular or in vivo experiments alone. Furthermore, it is difficult to design kinase… (More)
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Highly Cited
2012
Highly Cited
2012
Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative… (More)
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2011
2011
To identify regulators of intracellular signaling, we targeted 541 kinases and kinase-related molecules with small interfering… (More)
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Highly Cited
2007
Highly Cited
2007
The central role of protein kinases in signal transduction pathways has generated intense interest in targeting these enzymes for… (More)
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2006
2006
This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin… (More)
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Highly Cited
2004
Highly Cited
2004
We have determined the full protein kinase (PK) complement (kinome) of mouse. This set of 540 genes includes many novel kinases… (More)
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Highly Cited
2004
Highly Cited
2004
The DNA array technique allows comprehensive analysis of the genome and transcriptome, but the high throughput array-based… (More)
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