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Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
TLDR
Bystander lymphocyte apoptosis and loss of NK cells was a prominent finding, suggesting the importance of innate immunity in determining the fate of the host, and EBOV has evolved additional mechanisms to resist host defenses by inducing protective transcripts in cells that it infects. Expand
Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection
TLDR
The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies, and repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses. Expand
Smallpox as a biological weapon: medical and public health management. Working Group on Civilian Biodefense.
TLDR
Specific recommendations are made regarding smallpox vaccination, therapy, postexposure isolation and infection control, hospital epidemiology and infection Control, home care, decontamination of the environment, and additional research needs. Expand
Clinical recognition and management of patients exposed to biological warfare agents.
TLDR
A primer on 10 classic biological warfare agents is provided to increase the likelihood of their being considered in a differential diagnosis and the impact of a terrorist attack greatly reduced. Expand
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
TLDR
The etymological derivation of individual names, their pronunciation, and their correct use are explained, and demarcation criteria for each taxon and virus are elaborate. Expand
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
TLDR
The data suggest that these replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors are safe and highly efficacious in a relevant animal model. Expand
Ebola Virus Can Be Effectively Neutralized by Antibody Produced in Natural Human Infection
TLDR
The studies indicate that neutralizing antibodies are produced in infection by Ebola virus although probably at a relatively low frequency and the neutralizing antibody may be useful in vaccine design and as a prophylactic agent against Ebola virus infection. Expand
Preliminary report: isolation of Ebola virus from monkeys imported to USA
TLDR
This incident, the first in which a filovirus has been isolated from non-human primates without deliberate infection, raises the possibility that cynomolgus monkeys could be a reservoir of Ebola virus infection. Expand
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
TLDR
Data suggest that coagulation abnormalities associated with EBOV HF are not the direct result of E BOV-induced cytolysis of endothelial cells, and are likely triggered by immune-mediated mechanisms. Expand
Evaluation of candidate vaccine approaches for MERS-CoV
TLDR
It is shown that immunogens based on full-length S DNA and S1 subunit protein elicit robust serum-neutralizing activity against several MERS-CoV strains in mice and non-human primates. Expand
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