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KT 5823

Known as: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-, KT-5823, KT5823 
National Institutes of Health

Related topics

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2 relations

Broader (2)

CarbazolesProtein Kinase Inhibitors

Papers overview

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Highly Cited
2008
Highly Cited
2008
Postconditioning Prevents Reperfusion Injury by Activating &dgr;-Opioid Receptors
Background:While postconditioning has been proposed to protect the heart by targeting the mitochondrial permeability transition… 
Highly Cited
2003
Highly Cited
2003
Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA.
The role of RhoA in myosin light-chain (MLC)(20) dephosphorylation and smooth muscle relaxation by PKA and PKG was examined in… 
Highly Cited
2002
Highly Cited
2002
A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas.
Glucose homeostasis in blood is mainly maintained by insulin released from beta-cells and glucagon released from alpha-cells… 
Highly Cited
1999
Highly Cited
1999
Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling
Although nitric oxide (NO) induces neuronal cell death under some conditions, it also can prevent apoptosis resulting from growth… 
Highly Cited
1997
Highly Cited
1997
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
We exploited our observation that embryonic Xenopus spinal neurites align parallel to grooves in a quartz surface and that… 
Highly Cited
1997
Highly Cited
1997
The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan.
Highly Cited
1994
Highly Cited
1994
Stimulation of the Cyclic GMP Pathway by NO Induces Expression of the Immediate Early Genes c‐fos and junB in PC12 Cells
Abstract: Stimulation of several second messenger pathways induces the expression of immediate early genes such as c‐fos, c‐jun… 
Highly Cited
1994
Highly Cited
1994
Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.
Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor yet identified. This peptide plays an important role in the… 
Highly Cited
1993
Highly Cited
1993
Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis.
Involvement of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in neurally induced relaxation was examined in smooth… 
Highly Cited
1992
Highly Cited
1992
Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells
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