KT 5823

Known as: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))-, KT-5823, KT5823 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Tadalafil is a novel long-acting inhibitor of phosphodiesterase-5. Because cGMP-dependent protein kinase (PKG… (More)
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Highly Cited
2006
Highly Cited
2006
Nitric oxide (NO) has both prooxidant and antioxidant activities in the endothelium; however, the molecular mechanisms involved… (More)
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Highly Cited
2005
Highly Cited
2005
Ischemic and pharmacological preconditioning can be triggered by an intracellular signaling pathway in which Gi-coupled surface… (More)
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Highly Cited
2004
Highly Cited
2004
Canonical transient receptor potential (TRPC) channels are Ca2+-permeable nonselective cation channels that are widely expressed… (More)
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Highly Cited
1999
Highly Cited
1999
Apoptosis is a mode of cell death in which the cell participates in its own demise. We studied whether endothelium-derived… (More)
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Highly Cited
1999
Highly Cited
1999
Although nitric oxide (NO) induces neuronal cell death under some conditions, it also can prevent apoptosis resulting from growth… (More)
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Highly Cited
1998
Highly Cited
1998
Vascular endothelial growth factor (VEGF) is an endothelium-specific, secreted protein that acts as a vasodilator, angiogenic… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Abnormal proliferation of vascular smooth muscle cells (VSMC) is a key event in the pathogenesis of atherosclerosis… (More)
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Highly Cited
1995
Highly Cited
1995
Nitric oxide (NO) and angiotensin II (AII) can effect vascular smooth muscle cell (SMC) proliferation. However, the effects of… (More)
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Highly Cited
1994
Highly Cited
1994
The role of cGMP in myocardial contraction is not established. Recent reports suggest that nitric oxide, released by endothelial… (More)
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