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Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases.
We examined effect of iridoid glucosides, aucubin, catalpol, geniposide and gardenoside, and their enzymic hydrolysates on neurite outgrowth of PC12h cells. Except for aucubin, these glucosidesExpand
Activation of the mitogen‐activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells
Prominent neurite outgrowth induced by genipin, a plant‐derived iridoid, was substantially inhibited by addition of NG‐nitro‐l‐arginine methyl ester (l‐NAME), a nitric oxide (NO) synthase (NOS)Expand
Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells.
We have demonstrated previously that a natural iridoid compound, genipin, induced neuritogenesis through activation of nitric oxide synthase (NOS) and mitogen-activated protein kinase (MAPK) in PC12hExpand
Fundamental role of nitric oxide in neuritogenesis of PC12h cells
We investigated the neuritogenic action of nitric oxide (NO)‐generating agents and their mechanisms of action in a subclone of rat pheochromocytoma, PC12h cells. NO donors such as sodiumExpand
Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells.
Syringaresinol isolated from Epimedium koreanum NAKA1 and Magnolia officinalis REHD. et WILS. was subjected to optical resolution by chiral HPLC to give (+)- and (-)-enantiomers. The twoExpand
Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.
The MeOH extract of Epimedium sagittatum was found to show neurite outgrowth activity on cultured PC12h cells. Bioassay-guided fractionation of the MeOH extract yielded six prenylated flavonolExpand
Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells.
We have reported previously that genipin, a natural iridoid compound, induces neuritogenesis through a nitric oxide (NO)-cyclic GMP (cGMP)-cGMP-dependent protein kinase (PKG) signaling pathway inExpand
Prevention of the neurotoxicity of the amyloid beta protein by genipin.
Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity ofExpand
The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells
We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring itsExpand
Neuritogenic activities of 1-alkyloxygenipins.
We designed 1-alkyloxygenipins with the aim of improving the stability of genipins based on the structural and electronic properties of genipins, and prepared 1-alkyloxygenipins and examined theirExpand