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KNSTRN protein, human

Known as: Small Kinetochore-Associated Protein, Kinastrin, SKAP 
Small kinetochore-associated protein (316 aa, ~35 kDa) is encoded by the human KNSTRN gene. This protein plays a role in the progression of mitosis.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Cycle ControlCell Cycle ProgressionCentromereChromosome Segregation

Broader (2)

Cell Cycle ProteinsMicrotubule-Associated Proteins

Papers overview

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Highly Cited
2017
Highly Cited
2017
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells
Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on… 
2017
2017
Dual loss of p110&dgr; PI3‐kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features
2016
2016
Phosphorylation of Astrin Regulates Its Kinetochore Function*
The error-free segregation of chromosomes, which requires the precisely timed search and capture of chromosomes by spindles… 
2016
2016
Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests… 
2014
2014
Small Kinetochore Associated Protein (SKAP) Promotes UV-Induced Cell Apoptosis through Negatively Regulating Pre-mRNA Processing Factor 19 (Prp19)
Apoptosis is a regulated cellular suicide program that is critical for the development and maintenance of healthy tissues… 
2013
2013
Regulation of the Src Kinase-associated Phosphoprotein 55 Homologue by the Protein Tyrosine Phosphatase PTP-PEST in the Control of Cell Motility*
Background: PTP-PEST regulates cell migration as part of many protein complexes. Results: SKAP-Hom is a substrate of PTP-PEST… 
2011
2011
The Pleckstrin Homology Domain in the SKAP55 Adapter Protein Defines the Ability of the Adapter Protein ADAP To Regulate Integrin Function and NF-κB Activation
Adhesion and degranulation promoting adapter protein (ADAP) is a multifunctional hematopoietic adapter protein that regulates TCR… 
2009
2009
Expression of SKAP‐HOM in DCs is required for an optimal immune response in vivo
The cytosolic adaptor molecule SKAP‐HOM, similar to the T cell‐specific homologue SKAP55, interacts directly with ADAP, and both… 
Highly Cited
2005
Highly Cited
2005
Regulation of In Vitro and In Vivo Immune Functions by the Cytosolic Adaptor Protein SKAP-HOM
ABSTRACT SKAP-HOM is a cytosolic adaptor protein representing a specific substrate for the Src family protein tyrosine kinase Fyn… 
Highly Cited
1998
Highly Cited
1998
SKAP‐HOM, a novel adaptor protein homologous to the FYN‐associated protein SKAP55 1
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