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KNS2 protein, human

Known as: KLC 1, KLC1, Kinesin Light Chain 1 
Kinesin light chain 1 (573 aa, ~65 kDa) is encoded by the human KLC1 gene. This protein plays a role in microtubule motor activity.
National Institutes of Health

Related topics

Related topics

6 relations
Cellular MembraneIntracellular TransportKLC1 geneLigand Binding

Papers overview

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Highly Cited
2018
Highly Cited
2018
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Significance α-Synuclein (α-Syn) aggregation underlies neurodegeneration in synucleinopathies. However, the nature of α-Syn… 
Highly Cited
2014
Highly Cited
2014
A Novel Fusion of TPR and ALK in Lung Adenocarcinoma
Introduction: Anaplastic lymphoma kinase (ALK) fusion is the most common mechanism for overexpression and activation in non–small… 
Highly Cited
2009
Highly Cited
2009
Dynein and kinesin regulate stress-granule and P-body dynamics
Stress granules (SGs) and P-bodies (PBs) are related cytoplasmic structures harboring silenced mRNAs. SGs assemble transiently… 
Highly Cited
2009
Highly Cited
2009
Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the… 
2009
2009
Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains
Deficiency of caytaxin results in hereditary ataxia or dystonia in humans, mice and rats. Our yeast two-hybrid screen identified… 
Highly Cited
2006
Highly Cited
2006
Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
Highly Cited
2006
Highly Cited
2006
Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.
Kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) is a conserved membrane protein… 
Highly Cited
2005
Highly Cited
2005
Tubulin and CRMP‐2 complex is transported via Kinesin‐1
The transport of tubulin and microtubules in a growing axon is essential for axonal growth and maintenance. However, the… 
Highly Cited
2004
Highly Cited
2004
The Early Onset Dystonia Protein TorsinA Interacts with Kinesin Light Chain 1*
Early onset dystonia is a movement disorder caused by loss of a glutamic acid residue (Glu302/303) in the carboxyl-terminal… 
Highly Cited
2003
Highly Cited
2003
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.
Proteolytic processing of amyloid beta protein precursor (AbetaPP) generates peptides that regulate normal cell signaling and are… 
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