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KMUP 1

Known as: KMUP-1, KMUP1 cpd 
National Institutes of Health

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2 relations

Broader (2)

PiperidinesXanthines

Papers overview

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2016
2016
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice
KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However… 
2015
2015
Actions of KMUP‐1, a xanthine and piperazine derivative, on voltage‐gated Na+ and Ca2+‐activated K+ currents in GH3 pituitary tumour cells
7‐[2‐[4‐(2‐Chlorophenyl)piperazinyl]ethyl]‐1,3‐dimethylxanthine (KMUP‐1) is a xanthine‐based derivative. It has soluble GC… 
2015
2015
Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]
The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia… 
2013
2013
No Donor KMUP-1 Improves Hepatic Ischemia-Reperfusion and Hypoxic Cell Injury by Inhibiting Oxidative Stress and Pro-Inflammatory Signaling
This study investigates whether KMUP-1 improves hepatic ischemia-reperfusion (I/R) and hypoxic cell injury via inhibiting Nox2… 
2012
2012
Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
AIMS This study determines whether KMUP-1 inhalation suppresses ovalbumine (OVA)-sensitized and - challenged peri-bronchial… 
2011
2011
Kmup-1 Inhibits H441 Lung Epithelial Cell Growth, Migration and Proinflammation VIA Increased NO/CGMP and Inhibited RHO KINASE/VEGF Signaling Pathways
This study investigates whether KMUP-1 protects soluble guanylate cyclase (sGC) and inhibits vascular endothelial growth factor… 
2010
2010
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Background and purpose:  KMUP‐1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho… 
2010
2010
KMUP‐1 attenuates isoprenaline‐induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
Background and purpose:  To determine whether KMUP‐1, a novel xanthine‐based derivative, attenuates isoprenaline (ISO)‐induced… 
2009
2009
The Prostate 69 : 610 ^ 623 ( 2009 ) Piperazine-Designed a 1 A / a 1 D-AdrenoceptorBlocker KMUP-1 andDoxazosin ProvideDown-Regulationof AndrogenReceptor andPSAin Prostatic LNCaPCells Growthand…
Chi-Ming Liu, Yi-Ching Lo, Ming-Hong Tai, Bin-Nan Wu, Wen-Jeng Wu, Yii-Her Chou, Chee-Yin Chai, Chun-Hsiung Huang, and Ing-Jun… 
2005
2005
KMUP‐1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide‐dependent protein kinases
This study investigated whether KMUP‐1, a synthetic xanthine‐based derivative, augments the delayed‐rectifier potassium (KDR)‐ or… 
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