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KMUP 1

Known as: KMUP-1, KMUP1 cpd 
National Institutes of Health

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2 relations

Broader (2)

PiperidinesXanthines

Papers overview

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2015
2015
KMUP‐1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP‐2/Smad1/5/8 and Wnt/β‐Catenin
Phosphodiesterase (PDE) inhibitors have been suggested as a possible candidate for the treatment of osteopenia, including… 
2010
2010
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Background and purpose:  KMUP‐1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho… 
2010
2010
KMUP‐1 attenuates isoprenaline‐induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
Background and purpose:  To determine whether KMUP‐1, a novel xanthine‐based derivative, attenuates isoprenaline (ISO)‐induced… 
2009
2009
Piperazine‐designed α1A/α1D‐adrenoceptor blocker KMUP‐1 and doxazosin provide down‐regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts
KMUP‐1 has been suggested to be beneficial in the treatment of benign prostatic hyperplasia. This study is aimed to further… 
2007
2007
cGMP‐enhancing‐ and α1A/α1D‐adrenoceptor blockade‐derived inhibition of Rho‐kinase by KMUP‐1 provides optimal prostate relaxation and epithelial cell anti‐proliferation efficacy
Soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) and Rho kinase (ROCK2) pathways are… 
2006
2006
Inhibition of Proinflammatory Tumor Necrosis Factor-α-Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4…
In the study of anti-proinflammation by 7-[2-[4-(2-chlorobenzene)piperazinyl] ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4… 
2005
2005
KMUP‐1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide‐dependent protein kinases
This study investigated whether KMUP‐1, a synthetic xanthine‐based derivative, augments the delayed‐rectifier potassium (KDR)‐ or… 
2004
2004
KMUP‐1, a xanthine derivative, induces relaxation of guinea‐pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
7‐[2‐[4‐(2‐chlorophenyl)piperazinyl]ethyl]‐1,3‐dimethylxanthine (KMUP‐1) produces tracheal relaxation, intracellular accumulation… 
2002
2002
KMUP‐1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels
In isolated endothelium‐intact or denuded rabbit corpus cavernosum preconstricted with phenylephrine, KMUP‐1 (0.001 – 10 μM… 
Highly Cited
2001
Highly Cited
2001
A xanthine‐based KMUP‐1 with cyclic GMP enhancing and K+ channels opening activities in rat aortic smooth muscle
KMUP‐1 (1, 3, 5 mg kg−1, i.v.), a xanthine derivative, produced dose‐dependent sustained hypotensive and short‐acting… 
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