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KMUP 1
Known as:
KMUP-1
, KMUP1 cpd
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Piperidines
Xanthines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice
Bin-Nan Wu
,
K. Kuo
,
+5 authors
I. Chen
International Journal of Molecular Sciences
2016
Corpus ID: 4697930
KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However…
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2015
2015
Actions of KMUP‐1, a xanthine and piperazine derivative, on voltage‐gated Na+ and Ca2+‐activated K+ currents in GH3 pituitary tumour cells
Y. Lo
,
Y. Tseng
,
Chi-Ming Liu
,
Bin-Nan Wu
,
Sheng-Nan Wu
British Journal of Pharmacology
2015
Corpus ID: 13594495
7‐[2‐[4‐(2‐Chlorophenyl)piperazinyl]ethyl]‐1,3‐dimethylxanthine (KMUP‐1) is a xanthine‐based derivative. It has soluble GC…
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2015
2015
Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]
K. Kuo
,
Bin-Nan Wu
,
+5 authors
I. Chen
Journal of Lipid Research
2015
Corpus ID: 207008452
The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia…
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2011
2011
Kmup-1 Inhibits H441 Lung Epithelial Cell Growth, Migration and Proinflammation VIA Increased NO/CGMP and Inhibited RHO KINASE/VEGF Signaling Pathways
B. Wu
,
H. Chen
,
C.P. Liu
,
L. Hsu
,
I. Chen
International Journal of Immunopathology and…
2011
Corpus ID: 36856553
This study investigates whether KMUP-1 protects soluble guanylate cyclase (sGC) and inhibits vascular endothelial growth factor…
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2010
2010
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Hui-Hsuan Chung
,
Z. Dai
,
+5 authors
I. Chen
British Journal of Pharmacology
2010
Corpus ID: 205642712
Background and purpose: KMUP‐1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho…
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2010
2010
KMUP‐1 attenuates isoprenaline‐induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
J. Yeh
,
J. Hsu
,
+6 authors
Jiunn-ren Wu
British Journal of Pharmacology
2010
Corpus ID: 31946915
Background and purpose: To determine whether KMUP‐1, a novel xanthine‐based derivative, attenuates isoprenaline (ISO)‐induced…
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2010
2010
KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.
Z. Dai
,
Yu Cheng
,
Hui-Hsuan Chung
,
Jiunn-ren Wu
,
I. Chen
,
Bin-Nan Wu
Life Science
2010
Corpus ID: 31797653
2010
2010
KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.
Hui-Hsuan Chung
,
Z. Dai
,
+5 authors
I. Chen
Vascular pharmacology
2010
Corpus ID: 29881161
2009
2009
The Prostate 69 : 610 ^ 623 ( 2009 ) Piperazine-Designed a 1 A / a 1 D-AdrenoceptorBlocker KMUP-1 andDoxazosin ProvideDown-Regulationof AndrogenReceptor andPSAin Prostatic LNCaPCells Growthand…
Chi-Ming Liu
,
Y. Lo
,
+6 authors
I. Chen
2009
Corpus ID: 34292344
Chi-Ming Liu, Yi-Ching Lo, Ming-Hong Tai, Bin-Nan Wu, Wen-Jeng Wu, Yii-Her Chou, Chee-Yin Chai, Chun-Hsiung Huang, and Ing-Jun…
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2005
2005
KMUP‐1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide‐dependent protein kinases
Bin-Nan Wu
,
Hsiao-Fang Tu
,
D. Welsh
,
I. Chen
British Journal of Pharmacology
2005
Corpus ID: 13107071
This study investigated whether KMUP‐1, a synthetic xanthine‐based derivative, augments the delayed‐rectifier potassium (KDR)‐ or…
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