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KMUP 1
Known as:
KMUP-1
, KMUP1 cpd
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Piperidines
Xanthines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
KMUP‐1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP‐2/Smad1/5/8 and Wnt/β‐Catenin
S. Liou
,
J. Hsu
,
Hsin-Chieh Chu
,
Hung-Hong Lin
,
I. Chen
,
J. Yeh
Journal of Cellular Physiology
2015
Corpus ID: 24431932
Phosphodiesterase (PDE) inhibitors have been suggested as a possible candidate for the treatment of osteopenia, including…
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2010
2010
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Hui-Hsuan Chung
,
Z. Dai
,
+5 authors
I. Chen
British Journal of Pharmacology
2010
Corpus ID: 205642712
Background and purpose: KMUP‐1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho…
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2010
2010
KMUP‐1 attenuates isoprenaline‐induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways
J. Yeh
,
J. Hsu
,
+6 authors
Jiunn-ren Wu
British Journal of Pharmacology
2010
Corpus ID: 31946915
Background and purpose: To determine whether KMUP‐1, a novel xanthine‐based derivative, attenuates isoprenaline (ISO)‐induced…
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2009
2009
The Prostate 69 : 610 ^ 623 ( 2009 ) Piperazine-Designed a 1 A / a 1 D-AdrenoceptorBlocker KMUP-1 andDoxazosin ProvideDown-Regulationof AndrogenReceptor andPSAin Prostatic LNCaPCells Growthand…
Chi-Ming Liu
,
Y. Lo
,
+6 authors
I. Chen
2009
Corpus ID: 34292344
Chi-Ming Liu, Yi-Ching Lo, Ming-Hong Tai, Bin-Nan Wu, Wen-Jeng Wu, Yii-Her Chou, Chee-Yin Chai, Chun-Hsiung Huang, and Ing-Jun…
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2007
2007
cGMP‐enhancing‐ and α1A/α1D‐adrenoceptor blockade‐derived inhibition of Rho‐kinase by KMUP‐1 provides optimal prostate relaxation and epithelial cell anti‐proliferation efficacy
Chi-Ming Liu
,
Y. Lo
,
+5 authors
I. Chen
The Prostate
2007
Corpus ID: 24484086
Soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) and Rho kinase (ROCK2) pathways are…
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2006
2006
Inhibition of Proinflammatory Tumor Necrosis Factor-α-Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4…
Bin-Nan Wu
,
Chien-Wen Chen
,
S. Liou
,
J. Yeh
,
Hui-Hsuan Chung
,
I. Chen
Molecular Pharmacology
2006
Corpus ID: 19542062
In the study of anti-proinflammation by 7-[2-[4-(2-chlorobenzene)piperazinyl] ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4…
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2005
2005
KMUP‐1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide‐dependent protein kinases
Bin-Nan Wu
,
Hsiao-Fang Tu
,
D. Welsh
,
I. Chen
British Journal of Pharmacology
2005
Corpus ID: 13107071
This study investigated whether KMUP‐1, a synthetic xanthine‐based derivative, augments the delayed‐rectifier potassium (KDR)‐ or…
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2004
2004
KMUP‐1, a xanthine derivative, induces relaxation of guinea‐pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
Bin-Nan Wu
,
R. Lin
,
+4 authors
I. Chen
British Journal of Pharmacology
2004
Corpus ID: 10799807
7‐[2‐[4‐(2‐chlorophenyl)piperazinyl]ethyl]‐1,3‐dimethylxanthine (KMUP‐1) produces tracheal relaxation, intracellular accumulation…
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2002
2002
KMUP‐1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels
R. Lin
,
Bin-Nan Wu
,
+4 authors
I. Chen
British Journal of Pharmacology
2002
Corpus ID: 22692453
In isolated endothelium‐intact or denuded rabbit corpus cavernosum preconstricted with phenylephrine, KMUP‐1 (0.001 – 10 μM…
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Highly Cited
2001
Highly Cited
2001
A xanthine‐based KMUP‐1 with cyclic GMP enhancing and K+ channels opening activities in rat aortic smooth muscle
Bin‐nan Wu
,
R. Lin
,
Chiu‐Yin Lin
,
K. Shen
,
L. Chiang
,
I. Chen
British Journal of Pharmacology
2001
Corpus ID: 7198408
KMUP‐1 (1, 3, 5 mg kg−1, i.v.), a xanthine derivative, produced dose‐dependent sustained hypotensive and short‐acting…
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