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KMT2C gene

Known as: LYSINE-SPECIFIC METHYLTRANSFERASE 2C, KMT2C, MLL3 
This gene plays a role in both methylation and transcriptional regulation
National Institutes of Health

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Related topics

5 relations
MLL3 protein, humanMethylationProtein methylationTranscriptional Regulation

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MLL3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations.
2019
2019
SETD2, GIGYF2, FGFR3, BCR, KMT2C, and TSC2 as candidate genes for differentiating multilocular cystic renal neoplasm of low malignant potential from clear cell renal cell carcinoma with cystic change
Purpose Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) and clear cell renal cell carcinoma with cystic… 
2019
2019
Revealing clonality and subclonality of driver genes for clinical survival benefits in breast cancer
PurposeGenomic studies have revealed that genomic aberrations play important roles in the progression of this disease. The aim of… 
2017
2017
Role of MLL3 in regulating cardiac stem cells following cardiac cachexia.
OBJECTIVE Cardiac cachexia is a form of serious illness that results with terminal stage of heart failure. It is associated with… 
2016
2016
Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case–control study
A previous study indicated that MLL3 genetic polymorphisms were associated with human cancer. However, whether MLL3 genetic… 
2016
2016
Genetic Investigation of Uterine Carcinosarcoma: Case Report and Cohort Analysis.
BACKGROUND Uterine carcinosarcoma, a rare gynecological malignancy, often presents at the advanced stage with a poor prognosis… 
Review
2015
Review
2015
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Activating mutations of oncogenic RAS genes are frequently detected in human cancers. The studies in genetically engineered mouse… 
Highly Cited
2011
Highly Cited
2011
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.
2009
2009
Low frequency of MLL3 mutations in colorectal carcinoma.
2001
2001
Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.
We have identified and characterized the approximately 12-kb cDNA of a novel human gene (designated HALR for "homologous to ALR… 
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