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KLRC1 wt Allele

Known as: Killer Cell Lectin-Like Receptor, Subfamily C, Member 1 Gene, NKG2, Killer Cell Lectin-Like Receptor Subfamily C, Member 1 wt Allele 
Human KLRC1 wild-type allele is located in the vicinity of 12p13 and is approximately 12 kb in length. This allele, which encodes NKG2-A/NKG2-B type… 
National Institutes of Health

Related topics

Related topics

7 relations
12p13Immune responseKLRC3 geneLigand Binding

Broader (1)

KLRC1 gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B.
Highly Cited
2010
Highly Cited
2010
Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection
Background:The HIV-1-induced expansion of highly dysfunctional natural killer (NK) cell subsets represents a strategy to evade NK… 
Highly Cited
2008
Highly Cited
2008
Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure
Background: Natural killer (NK) cells may be impaired in patients with persistent hepatitis C virus (HCV) infection, but studies… 
Highly Cited
2006
Highly Cited
2006
Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells.
The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with… 
Highly Cited
2005
Highly Cited
2005
Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C
Introduction: Impaired activity of natural killer (NK) cells has been proposed as a mechanism contributing to viral persistence… 
Highly Cited
2004
Highly Cited
2004
Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection1
NK cells are potent activators of dendritic cells (DCs), but it remains obscure how third-party cells affect the ability of NK… 
Highly Cited
2001
Highly Cited
2001
Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2.
The stage of progenitor maturation and factors that determine the fate and clonal acquisition of human natural killer (NK) cell… 
Highly Cited
1999
Highly Cited
1999
Diversity of NK cell receptor repertoire in adult and neonatal mice.
Murine NK cytotoxicity is regulated by two families of MHC class I-specific receptors, namely Ly49 and CD94/NKG2. We developed a… 
Highly Cited
1997
Highly Cited
1997
Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.
NKG2 is a small family of type II transmembrane proteins possessing extracellular C-type lectin domains expressed primarily on NK… 
Highly Cited
1996
Highly Cited
1996
Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.
CD94 receptors expressed on NK cells have been implicated in the recognition of certain HLA class I allotypes. We now demonstrate… 
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