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KIR2DL1 gene

Known as: NKAT1, cl-42, KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR, TWO DOMAINS, LONG CYTOPLASMIC TAIL, 1 
This gene is involved in the regulation of natural killer cell activity.
National Institutes of Health

Related topics

Related topics

6 relations
Immune responseKIR2DL1 protein, humanKIR2DL1 wt AlleleKIR2DL2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells.
Inhibitory-cell killer immunoglobulin-like receptors (KIR) negatively regulate natural killer (NK) cell-mediated killing of HLA… 
Highly Cited
2008
Highly Cited
2008
Synergistic Polymorphism at Two Positions Distal to the Ligand-Binding Site Makes KIR2DL2 a Stronger Receptor for HLA-C Than KIR2DL31
Interactions between HLA-C ligands and inhibitory killer cell Ig-like receptors (KIR) control the development and response of… 
Highly Cited
2004
Highly Cited
2004
Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.
Highly Cited
2002
Highly Cited
2002
KIR2DL4 (CD158d), an NK Cell-Activating Receptor with Inhibitory Potential
KIR2DL4 (CD158d) is an unusual member of the killer cell Ig-like receptor family expressed in all NK cells and some T cells… 
Highly Cited
2001
Highly Cited
2001
Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1–HLA-Cw4 complex
Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I… 
Highly Cited
2001
Highly Cited
2001
The Repertoire of Killer Cell Ig-Like Receptor and CD94:NKG2A Receptors in T Cells: Clones Sharing Identical αβ TCR Rearrangement Express Highly Diverse Killer Cell Ig-Like Receptor Patterns1
Killer cell Ig-like receptor (KIR) and CD94:NKG2A molecules were first defined as human NK cell receptors (NKR), but now are… 
Highly Cited
2001
Highly Cited
2001
Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering
Natural killer (NK) cell cytotoxicity is determined by a balance of positive and negative signals. Negative signals are… 
Highly Cited
1999
Highly Cited
1999
Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties*
Human natural killer cells and a subset of T cells express a repertoire of killer cell immunoglobulin receptors (KIRs) that… 
Highly Cited
1998
Highly Cited
1998
Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors.
Natural killer (NK) cell cytotoxicity is regulated in large part by the expression of NK cell receptors able to bind class I… 
Highly Cited
1997
Highly Cited
1997
Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules
In an attempt to identify the amino acid position(s) of the HLA‐C‐specific p58.1/p50.1 natural killer cell receptors that… 
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