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Controlling natural killer cell responses: integration of signals for activation and inhibition.
Inhibitory receptors for major histocompatibility complex class I (MHC-I) have a critical role in controlling NK cell responses and, paradoxically, in maintaining NK cells in a state of responsiveness to subsequent activation events, a process referred to as licensing. Expand
Regulation of human NK-cell cytokine and chemokine production by target cell recognition.
Conceptually, the results point to CD56(dim) NK cells as an important source of cytokines and chemokines upon recognition of aberrant cells, producing graded responses depending on the multiplicity of activating receptors engaged. Expand
Repeated genes in eukaryotes.
A large number of the ribosomal genes affected by the bobbed locus mutation in Drosophila belong to the TSP class, which has been associated with central giant cell reprograming. Expand
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion.
Resting NK cells were induced to secrete tumor necrosis factor alpha and interferon gamma and to kill target cells by engagement of specific, pair-wise combinations of receptors, revealing distinct and specific patterns of synergy among receptors on resting NK cells. Expand
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.
Results show that KIR2DL receptors are specific for HLA-C, but that recognition of H LA-C allotypes appears more permissive than indicated by previous functional experiments. Expand
A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells
Recruitment of recombinant soluble KIR2DL4 into the cell line NK-92 resulted in inhibition of lysis of target cells that express HLA-G, but not target Cells that express other class I molecules including Hla-E. Expand
Regulation of immune responses through inhibitory receptors.
  • Eric O Long
  • Biology, Medicine
  • Annual review of immunology
  • 1999
The inhibitory-receptor superfamily appears to regulate many types of immune responses by blocking cellular activation signals. Expand
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
Using Drosophila insect cells, which express ligands of human NK cell receptors, it is shown that target cell lysis by resting NK cells is controlled by different receptor signals for cytolytic granule polarization and degranulation. Expand
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.
The data imply that the inhibitory function of p58 is dependent on its tyrosine phosphorylation and on recruitment and activation of HCP, and that introduction of an inactive mutant HCP into an NK cell line prevented the p58-mediated inhibition of target cell lysis. Expand
Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1–HLA-Cw4 complex
The crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to its class I MHC ligand, HLA-Cw4 is reported, which exhibits charge and shape complementarity. Expand