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KIF11 gene

Known as: HKSP, KINESIN FAMILY MEMBER 11, KIF11 
This gene plays a role in mitosis.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Cycle ControlChromosome SegregationKIF11 protein, humanKIF17 gene

Narrower (1)

KIF11 wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
The human kinesin Eg5 is a potential drug target for cancer chemotherapy. Eg5 specific inhibitors cause cells to block in mitosis… 
Highly Cited
2007
Highly Cited
2007
Load-dependent release limits the processive stepping of the tetrameric Eg5 motor
Tetrameric motor proteins of the Kinesin-5 family are essential for eukaryotic cell division. The microscopic mechanism by which… 
Highly Cited
2006
Highly Cited
2006
A structural model for monastrol inhibition of dimeric kinesin Eg5
Eg5 or KSP is a homotetrameric Kinesin‐5 involved in centrosome separation and assembly of the bipolar mitotic spindle… 
2006
2006
Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development.
A library of 2'-methoxyethyl-modified antisense oligonucleotides (2'MOE ASO) targeting 1,510 different genes has been developed… 
Highly Cited
2006
Highly Cited
2006
Inhibition of the Mitotic Kinesin Eg5 Up-regulates Hsp70 through the Phosphatidylinositol 3-Kinase/Akt Pathway in Multiple Myeloma Cells*
The microtubule-dependent motor protein Eg5 plays a critical role in spindle assembly and maintenance in mitosis. Herein we show… 
Highly Cited
2006
Highly Cited
2006
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint
Spindle poisons such as paclitaxel are widely used as cancer therapeutics. By interfering with microtubule dynamics, paclitaxel… 
2006
2006
Dimeric Eg5 Maintains Processivity through Alternating-site Catalysis with Rate-limiting ATP Hydrolysis*
Eg5/KSP is a homotetrameric, Kinesin-5 family member whose ability to cross-link microtubules has associated it with mitotic… 
Highly Cited
2006
Highly Cited
2006
A Pathway of Structural Changes Produced by Monastrol Binding to Eg5*
Monastrol is a small molecule inhibitor that is specific for Eg5, a member of the kinesin 5 family of mitotic motors… 
Highly Cited
2006
Highly Cited
2006
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
Highly Cited
1996
Highly Cited
1996
Kinetics and motility of the Eg5 microtubule motor.
We have investigated the kinetic properties of the slow plus end directed microtubule (MT) motor Eg5. The recombinantly expressed… 
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