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KIF11 gene

Known as: HKSP, KINESIN FAMILY MEMBER 11, KIF11 
This gene plays a role in mitosis.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Cycle ControlChromosome SegregationKIF11 protein, humanKIF17 gene

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KIF11 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Evidence of Carbon Fixation Pathway in a Bacterium from Candidate Phylum SBR1093 Revealed with Genomic Analysis
Autotrophic CO2 fixation is the most important biotransformation process in the biosphere. Research focusing on the diversity and… 
2012
2012
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Eg5/KSP is a promising mitotic spindle target for drug discovery in cancer chemotherapy and the development of agents against… 
2011
2011
Analysis of the interaction of the Eg5 Loop5 with the nucleotide site.
Highly Cited
2008
Highly Cited
2008
Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
The human kinesin Eg5 is a potential drug target for cancer chemotherapy. Eg5 specific inhibitors cause cells to block in mitosis… 
2008
2008
Proteome analysis of apoptosis signaling by S‐trityl‐L‐cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been… 
Highly Cited
2006
Highly Cited
2006
A Pathway of Structural Changes Produced by Monastrol Binding to Eg5*
Monastrol is a small molecule inhibitor that is specific for Eg5, a member of the kinesin 5 family of mitotic motors… 
2006
2006
Dimeric Eg5 Maintains Processivity through Alternating-site Catalysis with Rate-limiting ATP Hydrolysis*
Eg5/KSP is a homotetrameric, Kinesin-5 family member whose ability to cross-link microtubules has associated it with mitotic… 
Highly Cited
2006
Highly Cited
2006
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
2006
2006
Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.
2004
2004
Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation.
Eg5 is a kinesin-like motor protein required for mitotic progression in higher eukaryotes. It is thought to cross-link… 
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