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Drugs that target dynamic microtubules: A new molecular perspective
TLDR
The effects of microtubule‐binding chemotherapeutic agents are reviewed from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of micro Tubule assembly or disassembly.
HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients
TLDR
The first evidence of centrosome clustering-independent activities of HSET that fuel tumor progression is provided and it is firmly established that HSET can serve both as a potential prognostic biomarker and as a valuable cancer-selective therapeutic target.
Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.
TLDR
Two brominated derivatives of noscapine, 5- Br-nosc and reduced 5-bromonoscapine (Rd 5-Br- nosc) have higher tubulin binding activity than nos capine and affect tubulin polymerization differently from noscapINE, and are able to arrest cell cycle progression at mitosis at concentrations much lower than Noscapine.
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase.
TLDR
It is shown that adenovirus-mediated enhancement of the c-Jun NH2-terminal kinase (JNK) reduces the level of P-glycoprotein in a dose- and time-dependent manner and dramatically enhances the sensitivity of MDR cancer cells to chemotherapeutic agents.
Stromal PD-L1 Expression Is Associated With Better Disease-Free Survival in Triple-Negative Breast Cancer.
TLDR
PD-L1 expression is seen in a high proportion of TNBCs and associated with better DFS, and TILs and LVI were significantly associated with metastasis in univariate analysis and in multivariate analysis.
Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy
TLDR
Progress made towards demystifying this riddling cellular tactic and exploiting it for chemotherapeutic purposes are detailed, and a model to highlight the integral role of microtubule dynamicity and the delicate balance of forces on which cancer cells rely for effective centrosome clustering is proposed.
Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast
TLDR
Touching TILs provides a reproducible method for their assessment that can potentially be used to guide management and be associated with strongest prognostic value in breast ductal carcinoma in situ (DCIS).
Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer.
TLDR
The data indicate that despite lower absorption and bioavailability of rutin, maximum efficacy was achieved in the case of GLE, which also comprises of other phytochemical groups including acetogenins that make up its natural complex environment.
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