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KDR wt Allele

Known as: VEGFR, CD309, FLK1 
Human KDR wild-type allele is located within 4q11-q12 and is approximately 47 kb in length. This allele, which encodes vascular endothelial growth… 
National Institutes of Health

Related topics

Related topics

16 relations
4q11-q12Angiogenesis PathwayAngiogenic ProcessFocal adhesion pathway

Papers overview

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Highly Cited
2011
Highly Cited
2011
Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension
Rationale: Pulmonary arterial hypertension (PAH) is an incurable disease associated with viral infections and connective tissue… 
Highly Cited
2010
Highly Cited
2010
Vascular endothelial growth factor is involved in mediating increased de novo hippocampal neurogenesis in response to traumatic brain injury.
Stimulating the endogenous repair process after traumatic brain injury (TBI) can be an important approach in neuroregenerative… 
Highly Cited
2007
Highly Cited
2007
FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish.
Highly Cited
2006
Highly Cited
2006
Amplification of KIT, PDGFRA, VEGFR2, and EGFR in Gliomas
Receptor tyrosine kinase aberrations are implicated in the genesis of gliomas. We investigated expression and amplification of… 
Highly Cited
2006
Highly Cited
2006
Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells.
Go/Gi coupled G-protein receptor mediated transactivation is critical in the activation of receptor tyrosine kinases (RTK). Here… 
Highly Cited
2004
Highly Cited
2004
Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice
Background. Fibrosis is the common end stage of most liver diseases, for which, unfortunately, there is no effective treatment… 
Highly Cited
2003
Highly Cited
2003
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse.
Mouse embryos mutant for the VEGF receptor, VEGFR2, Flk-1, or Kdr, fail to form both endothelial and hematopoietic cells… 
Highly Cited
2002
Highly Cited
2002
Active Immunization Against the Vascular Endothelial Growth Factor Receptor flk1 Inhibits Tumor Angiogenesis and Metastasis
The vascular endothelial growth factor (VEGF) receptor fetal liver kinase 1 (flk1; VEGFR-2, KDR) is an endothelial cell–specific… 
Highly Cited
2001
Highly Cited
2001
Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or the expression of VEGF, FLK1 or FLT1
Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or… 
Highly Cited
1998
Highly Cited
1998
Direct visualization of renal vascular morphogenesis in Flk1 heterozygous mutant mice.
Flk1, a receptor tyrosine kinase for vascular endothelial growth factor (VEGF), is the earliest known marker for endothelial… 
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