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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by mechanisms that are not completely understood. Fusion between early endosomes requires phosphatidyl-inositol-3-OHExpand
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The Rab5 effector EEA1 is a core component of endosome docking
Intracellular membrane docking and fusion requires the interplay between soluble factors and SNAREs. The SNARE hypothesis postulates that pairing between a vesicular v-SNARE and a target membraneExpand
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Phosphatidylinositol-3-OH kinases are Rab5 effectors
*Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse, 01307 Dresden, Germany †European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, GermanyExpand
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APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment
Signals generated in response to extracellular stimuli at the plasma membrane are transmitted through cytoplasmic transduction cascades to the nucleus. We report the identification of a pathwayExpand
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Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain
Rab5 regulates endocytic membrane traffic by specifically recruiting cytosolic effector proteins to their site of action on early endosomal membranes. We have characterized a new Rab5 effectorExpand
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The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms
The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5Expand
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An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
Generation and turnover of phosphoinositides (PIs) must be coordinated in a spatial- and temporal-restricted manner. The small GTPase Rab5 interacts with two PI 3-kinases, Vps34 and PI3Kβ, suggestingExpand
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Distinct Rab‐binding domains mediate the interaction of Rabaptin‐5 with GTP‐bound rab4 and rab5
Rabaptin‐5 functions as an effector for the small GTPase Rab5, a regulator of endocytosis and early endosome fusion. We have searched for structural determinants that confer functional specificity onExpand
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The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
How epidermal growth factor receptor (EGFR) signalling is linked to EGFR trafficking is largely unknown. Signalling and trafficking involve small GTPases of the Rho and Rab families, respectively.Expand
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A complete Rab screening reveals novel insights in Weibel–Palade body exocytosis
Summary Weibel–Palade bodies (WPBs) are endothelial-cell-specific organelles that, upon fusion with the plasma membrane, release cargo molecules that are essential in blood vessel abnormalities, suchExpand
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