Skip to search formSkip to main contentSkip to account menu

KDM6B gene

Known as: LYSINE-SPECIFIC DEMETHYLASE 6B, lysine demethylase 6B, JUMONJI DOMAIN-CONTAINING PROTEIN 3 
This gene plays a role in both cellular differentiation and histone demethylation.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Differentiation processDevelopmental processHistone Demethylase JMJD3KDM4D gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines.
2018
2018
AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway
Aberrations in histone modifications are being studied in mixed-lineage leukemia (MLL)-AF9-driven acute myeloid leukemia (AML… 
2018
2018
Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation
ABSTRACT Homeobox (HOX) genes are frequently dysregulated in leukemia. Previous studies have shown that aberrant HOX gene… 
2017
2017
Dexamethasone suppresses JMJD3 gene activation via a putative negative glucocorticoid response element and maintains integrity of tight junctions in brain microvascular endothelial cells
The blood–brain barrier (BBB) exhibits a highly selective permeability to support the homeostasis of the central nervous system… 
Review
2017
Review
2017
Novel flavonol analogues as potential inhibitors of JMJD3 histone demethylase-A study based on molecular modelling.
2016
2016
Down-regulation of EZH2 expression in myelodysplastic syndromes.
2016
2016
A Clinical Study of OPN-305, a Toll-like Receptor 2 (TLR-2) Antibody, in Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have Received Prior Hypomethylating Agent (HMA) Therapy
INTRODUCTION: Alterations of innate immune signaling, including overexpression of TLR2, are common in MDS. Signaling mediated by… 
Review
2016
Review
2016
The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives.
Aberrant epigenetic reprogramming occurs frequently in the development of tumors. Histone H3 lysine 27 trimethylation (H3K27me3… 
2015
2015
Histone demethylase JMJD3 is required for osteoblast differentiation in mice
JMJD3 (KDM6B) is an H3K27me3 demethylases and emerges as an important player in developmental processes. Although some evidence… 
Review
2014
Review
2014
Molecular basis for substrate recognition by lysine methyltransferases and demethylases.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)