• Publications
  • Influence
Leptin regulation of bone resorption by the sympathetic nervous system and CART
TLDR
This study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure.
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
TLDR
It is shown that the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, colocalizes with master growth regulator mTOR complex 1 (mTORC1) on the lysOSomal membrane and the Rag GTPase complex is both necessary and sufficient to regulate starvation‐ and stress‐induced nuclear translocation of TFEB.
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
TLDR
Mgp, a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
TLDR
It is shown that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype, and it is demonstrated that this phenotype becomes evident postnatally, and that it is secondary to decreased osteoblast proliferation and function in a Cbfa1-independent manner.
...
...