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K 252a

Known as: K252A, Protein Kinase Inhibitor K252a, 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)- 
A fungal alkaloid from Nocardiopsis species, which inhibits protein kinase C. (NCI)
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

staurosporine aglycone

Papers overview

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Highly Cited
2002
Highly Cited
2002
Mixed lineage kinase activity of indolocarbazole analogues.
Highly Cited
2002
Highly Cited
2002
K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK*
K252a is best known as a Trk inhibitor, but is also a neuroprotective compound. CEP1347, a K252a derivative, retains… 
Highly Cited
2001
Highly Cited
2001
Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway
ABSTRACT Atypical protein kinase C (PKC) isoforms are required for nerve growth factor (NGF)-initiated differentiation of PC12… 
Highly Cited
2000
Highly Cited
2000
Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons.
Phosphorylation of the neurofilament-H subunit (NF-H) was investigated in rat embryonic brain neurons in culture. A portion of… 
Highly Cited
1998
Highly Cited
1998
Neurotrophins Rapidly Modulate Growth Cone Response to the Axon Guidance Molecule, Collapsin-1
We show that neurotrophins acting at the growth cone via Trk receptors can mediate rapid and distinct changes in growth cone… 
Highly Cited
1997
Highly Cited
1997
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors
Highly Cited
1994
Highly Cited
1994
A role for protein kinases and phosphatases in the Ca2+-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses
Highly Cited
1991
Highly Cited
1991
Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a
The staurosporine analogues, K-252a and RK-286C, were found to cause DNA re-replication in rat diploid fibroblasts (3Y1) without… 
Highly Cited
1991
Highly Cited
1991
Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926.
Highly Cited
1988
Highly Cited
1988
K-252a, a potent protein kinase inhibitor, blocks nerve growth factor- induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells
Nerve growth factor (NGF) promotes neuronal differentiation of PC12 pheochromocytoma cells. One of the most prominent and… 
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