K 252a

Known as: K252A, Protein Kinase Inhibitor K252a, 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)- 
A fungal alkaloid from Nocardiopsis species, which inhibits protein kinase C. (NCI)
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases… (More)
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Highly Cited
1999
Highly Cited
1999
Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells, and it promotes angiogenesis in vivo. Here we… (More)
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Highly Cited
1998
Highly Cited
1998
PM28A is a major intrinsic protein of the spinach leaf plasma membrane and the major phosphoprotein. Phosphorylation of PM28A is… (More)
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Highly Cited
1997
Highly Cited
1997
Brain-derived neurotrophic factor (BDNF) is one of neurotrophins involved in the development and maintenance of both the… (More)
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Highly Cited
1995
Highly Cited
1995
The neurotrophins are signaling factors important for the differentiation and survival of distinct neuronal populations during… (More)
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Highly Cited
1992
Highly Cited
1992
The rat pheochromocytoma PC12 cell line differentiates into a sympathetic neuronal phenotype upon treatment with either nerve… (More)
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Review
1992
Review
1992
K-252 compounds, which share a common polyaromatic aglycon structure, are rather general and potent inhibitors of various protein… (More)
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Highly Cited
1988
Highly Cited
1988
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth… (More)
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Highly Cited
1987
Highly Cited
1987
K-252 compounds (K-252a and b isolated from Nocardiopsis sp. (1) and their synthetic derivatives) were found to inhibit cyclic… (More)
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Highly Cited
1986
Highly Cited
1986
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent… (More)
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