Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

K 252a

Known as: K252A, Protein Kinase Inhibitor K252a, 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)- 
A fungal alkaloid from Nocardiopsis species, which inhibits protein kinase C. (NCI)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
  • F. Lee, M. Chao
  • Proceedings of the National Academy of Sciences…
  • 2001
  • Corpus ID: 20802623
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells, and it promotes angiogenesis in vivo. Here we… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1998
Highly Cited
1998
PM28A is a major intrinsic protein of the spinach leaf plasma membrane and the major phosphoprotein. Phosphorylation of PM28A is… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The neurotrophins are signaling factors important for the differentiation and survival of distinct neuronal populations during… Expand
Is this relevant?
Highly Cited
1992
Highly Cited
1992
K252a, an efficient serine/threonine protein kinase inhibitor (IC50s of 10 to 30 nM), has been shown to block the neuronal… Expand
Is this relevant?
Highly Cited
1992
Highly Cited
1992
The rat pheochromocytoma PC12 cell line differentiates into a sympathetic neuronal phenotype upon treatment with either nerve… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1989
Highly Cited
1989
A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial… Expand
Is this relevant?
Highly Cited
1988
Highly Cited
1988
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
1987
Highly Cited
1987
K-252 compounds (K-252a and b isolated from Nocardiopsis sp. (1) and their synthetic derivatives) were found to inhibit cyclic… Expand
Is this relevant?
Highly Cited
1986
Highly Cited
1986
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent… Expand
Is this relevant?