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JTV 506

Known as: JTV-506 
National Institutes of Health

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Papers overview

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2004
2004
JTV-506, a new KATP channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats
PurposeVasodilators are considered effective in the treatment of pulmonary hypertension if the vascular reactivity remains… 
2003
2003
[Opening of ATP-sensitive potassium channel attenuates cardiac remodeling induced by chronic inhibition of nitric oxide synthesis].
OBJECTIVES We examined whether the ATP-sensitive potassium(KATP) channel openers (KCOs) block myocardial hypertrophy, and whether… 
2000
2000
[Effects of a novel KATP channel opener JTV-506 on myocardial infarct size of isolated rat heart].
AIM To study the influence of a novel KATP channel opener JTV-506(JTV) on cardiac function and myocardial infarct size of… 
1999
1999
Systemic and coronary hemodynamic effects of JTV-506, a novel potassium channel opener, in conscious dogs: comparison with cromakalim and nicorandil.
We compared the coronary and systemic hemodynamic effects of JTV-506, a novel potassium channel opener, with those of cromakalim… 
1999
1999
Effects of the New Potassium Channel Opener JTV-506 on Coronary Vessels in vitro and in vivo
Summary The vascular effects of JTV-506 ((-)-(3S,4R)-2,2-bis(methoxymethyl)-4-[(1,6-dihydro- 1-methyl-6-oxo-3-pyridazinyl)amino… 
1999
1999
[Effects of an ATP-sensitive K+ channel activator, JTV-506, on antigen-induced early and late asthmatic responses in sensitized guinea pigs].
Effects of an ATP-sensitive K+ channel activator, JTV-506, on dual asthmatic responses and airway inflammation after antigen… 
1998
1998
Effect of JTV-506, a novel vasodilator, on experimental angina model in rats.
The antianginal effects of JTV-506, a newly synthesized 2,2-bis-methoxymethyl benzopyran-derivative potassium channel opener… 
1997
1997
Effects of JTV‐506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure
Background ATP‐sensitive K+ (KATP) channel activators produce relaxation of smooth muscle in many tissues. However, this wide… 
1997
1997
Effect of JTV-506, a novel vasodilator, on coronary blood flow in conscious dogs.
Coronary vasodilator and hemodynamic profiles of JTV-506, a newly synthesized 2,2-bis-methoxymethyl benzopyran-derivative… 
1996
1996
Synthesis and selective coronary vasodilatory activity of 3,4-dihydro-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol derivatives: novel potassium channel openers.
A variety of compounds having a benzopyran such as levcromakalim generally exhibit potent antihypertensive activity. During… 
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