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Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
TLDR
Testing the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish found it to be a promising treatment. Expand
Gramicidin‐perforated patch recording: GABA response in mammalian neurones with intact intracellular chloride.
TLDR
The gramicidin‐perforated patch method will disclose previously unknown aspects of biological responses involving Cl‐, indicating that the membrane behaves like a chloride electrode in the presence of GABA. Expand
Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells*
TLDR
Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells, indicating the inter-species difference in the hypoxic regulation ofHO-1 expression. Expand
Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol.
TLDR
The RV FDG accumulation corrected for the partial volume effect was significantly increased in accordance with the severity of the RV pressure overload in patients with pulmonary hypertension and was decreased after the treatment with epoprostenol. Expand
Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways.
TLDR
RNS may be involved in the pathobiology of the airway inflammatory and obstructive process in COPD; and NO produced in the airways, presumably via iNOS, is consumed by its reaction with superoxide anion and/or peroxidase-dependent mechanisms. Expand
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
TLDR
It is suggested that hypoxia induced the release of Glut in NTS and that this effect was mediated by arterial chemosensory input. Expand
Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia.
TLDR
Evidence is provided that, in the NTS, NO works as a retrograde messenger in an L‐glutamate‐releasing positive feedback system contributing to the augmentation of ventilation during hypoxia, the first in vivo evidence that the role of nitric oxide in respiratory regulation in the nucleus tractus solitarii is examined. Expand
Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma.
TLDR
Reduced chemosensitivity to hypoxia and blunted perception of dyspnea may predispose patients to fatal asthma attacks. Expand
Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
TLDR
EPA was effective in reducing the incidence of CAD events for patients with this dyslipidemic pattern, suggesting that EPA may be especially beneficial in patients who with abnormal TG and HDL-C levels. Expand
Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1.
TLDR
Results indicate that hypoxia induces ETS-1 via the activity of HIF-1, and double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the Hypoxia-mediated inducibility. Expand
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