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4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.
TLDR
Results indicate that this nociceptin antagonist has the potential to become a novel type of analgesic that differs from mu-opioid agonists. Expand
Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives.
TLDR
A platelet activating factor (PAF) antagonist, designated as FR-49175, was isolated from fermentation products of Penicillium terlikowskii and identified as bisdethiobis(methylthio)-gliotoxin, which showed the most potent PAF inhibitory activity. Expand
bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein.
TLDR
This study elucidated the structural requirements for inhibitory activity and determined that the optimum compound was S-(2-((1-ethylbutyl)cyclohexane)carbonylamino)phenyl) 2-methylpropanethioate (27) (JTT-705). Expand
A malonylated anthocyanin and flavonols in blue Meconopsis flowers.
TLDR
The structures of the major anthocyanin and two flavonols from the blue flowers of Meconopsis were identified by NMR spectroscopy as being cyanidin 3-O, 7-O-beta-D-glucopyranoside, and kaempferol3-O. Expand
Isolation and characterization of cardiac steroids from seeds of Elaeopendron glaucum Pers. Structures of elaeodendrosides A, D, E, H, I, J and elaeodendrogenin.
Six cardiac glycosides having a methylenedioxy group in the sugar moiety, elaeodendroside A, D, E, H, I and J, were isolated from seeds of Elaeodendron glaucum PERS. Their structures were elucidatedExpand
Structures of elaeodendrosides B, C, F, G, K and L, a series of cardiac glycosides isolated from Elaeodendron glaucum
Abstract Six cardiac glycosides having an unusual sugar linkage, elaeodendrosides B, C, F, G, K and L, were isolated from seeds of Elaeodendron glaucum . These were characterized on the basis of theExpand
Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models.
TLDR
The effect of this compound against a systemic anaphylaxis model in guinea-pigs was examined, but it did not show any inhibition of antigen-induced mortality at the dose of 10 mg/kg, i.v. Expand
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