JTT 705

MD-2 is a part of the Toll-like 4 signaling complex with an indispensable role in activation of the lipopolysaccharide (LPS… (More)

INTRODUCTION While elevated plasma HDL levels are inversely correlated with cardiovascular events, raising HDL with the CETP… (More)

BACKGROUND Despite reduction in low-density lipoprotein cholesterol, there is still a considerable amount of residual… (More)

The excessive proliferation and migration of vascular smooth muscle cells (SMCs) participate in the growth and instability of… (More)

JTT-705 is a cholesteryl ester transfer protein inhibitor under development by Japan Tobacco Inc for the treatment of… (More)

BACKGROUND Inhibition of cholesteryl ester transfer protein (CETP) is an efficient way to increase high-density lipoprotein (HDL… (More)

This study evaluated JTT-705, S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate, as a cholesteryl… (More)

Cholesteryl ester transfer protein (CETP) is a major determinant of plasma levels of high-density lipoprotein-cholesterol (HDL-C… (More)

We have previously reported a potent and specific cholesteryl ester transfer protein (CETP) inhibitor JTT-705 was a potentially… (More)

Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of cholesteryl ester in high-density… (More)