JTT 705

The plasma levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Traditional HDL… Expand

Systematic identification of protein-drug interaction networks is crucial to correlate complex modes of drug action to clinical… Expand

INTRODUCTION While elevated plasma HDL levels are inversely correlated with cardiovascular events, raising HDL with the CETP… Expand

Because cholesteryl ester transfer protein (CETP) inhibition is a potential HDL-raising therapy, interest has been raised in the… Expand

The last 20 years have witnessed dramatic reductions in cardiovascular risk using 3-hydroxy-3-methylglutaryl coenzyme A reductase… Expand

Innovative pharmacological approaches to raise anti-atherogenic high-density lipoprotein-cholesterol (HDL-C) are currently of… Expand

The inhibition of cholesteryl ester transfer protein (CETP) has recently been shown to effectively increase high-density… Expand

Cholesteryl ester transfer protein (CETP) is a major determinant of plasma levels of high-density lipoprotein-cholesterol (HDL-C… Expand

We have previously reported a potent and specific cholesteryl ester transfer protein (CETP) inhibitor JTT-705 was a potentially… Expand

Of late, there has been a major renewal of interest into the protective effect of high-density lipoprotein (HDL)cholesterol on… Expand