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dalcetrapib

Known as: S-(2-((1-(2-ethylbutyl)cyclohexane)carbonylamino)phenyl) 2-methylpropanethioate 
A cholesteryl ester transfer protein (CETP) inhibitor that can produce an increase in serum HDL-cholesterol levels and a decrease in serum LDL… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anticholesteremic AgentsSulfhydryl Compounds

Narrower (2)

JTT 705R1658

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Impact of ADCY9 Genotype on Response to Anacetrapib
Supplemental Digital Content is available in the text. 
2017
2017
CETP Inhibitors - A New Inning?
Former baseball manager Tony La Russa once said, “Even when you have three strikes, you’re still not out. There is always… 
Review
2015
Review
2015
Targeting High-density Lipoproteins to Reduce Cardiovascular Risk: What Is the Evidence?
Highly Cited
2015
Highly Cited
2015
Statin-Induced Decrease in ATP-Binding Cassette Transporter A1 Expression via microRNA33 Induction may Counteract Cholesterol Efflux to High-Density Lipoprotein
PurposeCholesterol efflux from macrophages to HDL, measured in vitro, is augmented by treatment with agents which raise HDL… 
2013
2013
Evidence for a role of CETP in HDL remodeling and cholesterol efflux: role of cysteine 13 of CETP.
Highly Cited
2012
Highly Cited
2012
Tangier disease: epidemiology, pathophysiology, and management.
Tangier disease is one of the most severe forms of familial high-density lipoprotein (HDL) deficiency. Since its discovery it has… 
2010
2010
Lack of effect of dalcetrapib on QT interval in healthy subjects following multiple dosing
PurposeEvaluate dalcetrapib’s potential to prolong QT intervals in healthy subjects.MethodsThis was a single-center, randomized… 
2010
2010
Coadministration of Dalcetrapib With Pravastatin, Rosuvastatin, or Simvastatin: No Clinically Relevant Drug‐Drug Interactions
Dalcetrapib targets cholesteryl ester transfer protein and increases high‐density lipoprotein cholesterol (HDL‐C) levels. It is… 
Highly Cited
2009
Highly Cited
2009
Dalcetrapib: no off‐target toxicity on blood pressure or on genes related to the renin‐angiotensin‐aldosterone system in rats
Background and purpose:  The association between torcetrapib and its off‐target effects on blood pressure suggested a possible… 
2009
2009
In vitro and in vivo assessment of the effect of dalcetrapib on a panel of CYP substrates
ABSTRACT Objective: The primary objective of this study was to investigate the drug–drug interaction potential of dalcetrapib on… 
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