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JNK cascade

Known as: c-Jun N-terminal kinase cascade 
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two… 
National Institutes of Health

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JNK1 cascade

Papers overview

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2015
2015
The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade
Here, we report the p53 dependent mitochondria-mediated apoptotic mechanism of plant derived silver-nanoparticle (PD-AgNPs) in… 
2015
2015
Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family
Noonan syndrome (NS) is a genetic condition characterized by congenital heart defects, short stature and characteristic facial… 
Review
2014
Review
2014
The impact of JNK on neuronal migration.
Incorrect placement of nerve cells during brain development leaves us at risk of diseases and conditions ranging from epilepsy… 
2007
2007
c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis.
2004
2004
Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells.
2004
2004
The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia
Deficiency in cystathionine beta synthase (CBS) leads to high plasma homocysteine concentrations and causes hyperhomocysteinemia… 
2003
2003
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
Exhaled nitric oxide (NO) is increased in individuals with bronchial asthma. NO may have antiinflammatory and proinflammatory… 
Highly Cited
2002
Highly Cited
2002
Protein Phosphatase 4 Is Involved in Tumor Necrosis Factor-α-induced Activation of c-Jun N-terminal Kinase*
Protein phosphatase 4 (PP4, previously named protein phosphatase X (PPX)), a PP2A-related serine/threonine phosphatase, has been… 
2000
2000
Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils.
In response to cellular stress, the activation of the JNK cascade mediates phosphorylation of c-Jun that promotes its… 
Highly Cited
1999
Highly Cited
1999
The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the I kappa B kinase cascade.
Costimulation of TCR/CD3 and CD28 receptors leads to activation of the Jun kinase (JNK) cascade, which plays a key role in T cell… 
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