A Simple Role for BDNF in Learning and Memory?
- Carla Cunha, R. Brambilla, K. Thomas
- BiologyFrontiers in Molecular Neuroscience
- 8 October 2009
It is shown that maturation of BDNF, its cellular localization and its ability to regulate both excitatory and inhibitory synapses in the CNS may result in conflicting alterations in synaptic plasticity and memory formation.
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
- R. Klein, I. Silos-santiago, M. Barbacid
- BiologyNature
- 17 March 1994
It is shown that homozygous mice defective for TrkC tyrosine protein kinase receptors lack la muscle afferent projections to spinal motor neurons and have fewer large myelinated axons in the dorsal root and posterior columns of the spinal cord, indicating that NT3/TrkC-dependent sensory neurons may play a primary role in proprioception, the sense of position and movement of the limbs.
Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
- C. Mazzucchelli, C. Vantaggiato, R. Brambilla
- Biology, PsychologyNeuron
- 30 May 2002
A role for the Ras signalling pathway in synaptic transmission and long-term memory
- R. Brambilla, N. Gnesutta, R. Klein
- BiologyNature
- 20 November 1997
It is reported that mice lacking Ras-GRF are impaired in the process of memory consolidation, as revealed by emotional conditioning tasks that require the function of the amygdala; learning and short-term memory are intact.
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
- C. Vantaggiato, Ivan Formentini, A. Bondanza, C. Bonini, L. Naldini, R. Brambilla
- BiologyJournal of Biology
- 28 June 2006
An unexpected interplay between ERK1 and ERK2 in transducing Ras-dependent cell signaling and proliferation is revealed in mouse embryo fibroblasts and NIH 3T3 cells.
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
- Matthieu F. Bastide, W. Meissner, E. Bézard
- Psychology, BiologyProgress in neurobiology
- 1 September 2015
Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa–induced dyskinesia
- S. Fasano, E. Bézard, R. Brambilla
- Biology, PsychologyProceedings of the National Academy of Sciences
- 29 November 2010
In a nonhuman primate model of LID, lentiviral vectors expressing dominant negative forms of Ras-GRF1 caused a dramatic reversion of dyskinesia severity leaving intact the therapeutic effect of l-dopa.
Knockout of ERK1 Enhances Cocaine-Evoked Immediate Early Gene Expression and Behavioral Plasticity
- S. Ferguson, S. Fasano, Pengwei Yang, R. Brambilla, T. Robinson
- Biology, PsychologyNeuropsychopharmacology
- 1 December 2006
It is reported here that deletion of the ERK1 isoform, which leads to increased ERK2 stimulus-dependent signaling, facilitates the development of cocaine-induced psychomotor sensitization and the acquisition of a cocaine conditioned place preference.
Ras-related and MAPK signalling in neuronal plasticity and memory formation
- C. Mazzucchelli, R. Brambilla
- BiologyCellular and Molecular Life Sciences (CMLS)
- 1 April 2000
The experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes is discussed.
ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites
- A. Bergemann, H. Cheng, R. Brambilla, R. Klein, J. Flanagan
- BiologyMolecular and Cellular Biology
- 1 September 1995
A new member of the Eph ligand family is described, designated ELF-2, which shows closest homology to the other known transmembrane ligand in the family, ELK-L/LERK-2/Cek5-L, with 57% identity in the extracellular domain and striking homology in the cytoplasmic domain.
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