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JAG2 protein, human

Known as: Protein Jagged-2, Jagged 2, Jagged2 
Protein jagged-2 (1238 aa, ~133 kDa) is encoded by the human JAG2 gene. This protein plays a role in cellular differentiation.
National Institutes of Health

Related topics

Related topics

15 relations
Cell Differentiation processCell Fate ControlEGF-Like DomainIntegral Membrane Proteins

Broader (1)

Jagged-2 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Notch signaling and the developing inner ear.
Sensory hair cells (HCs) and their associated nonsensory supporting cells (SCs) exhibit a typical mosaic pattern in each of the… 
Highly Cited
2009
Highly Cited
2009
Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti
Highly Cited
2008
Highly Cited
2008
Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells1
Expression of the Jagged Notch ligands by dendritic cells (DCs) has been suggested to play a role in instructing Th2 responses… 
Highly Cited
2008
Highly Cited
2008
Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection1
Recent reports demonstrated that dendritic cells (DC) sense inflammatory and microbial signals differently, redefining their… 
Highly Cited
2005
Highly Cited
2005
Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens.
In order to identify tumor-associated genes of ovarian carcinoma, we have investigated the transcriptional profile of 11 ovarian… 
Highly Cited
2000
Highly Cited
2000
A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea
Highly Cited
2000
Highly Cited
2000
Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact.
To study the regulation of the early stages of hematopoiesis, cDNA representational difference analysis was used to isolate genes… 
2000
2000
CADASIL: Notch signaling defect or protein accumulation problem?
When studies of the genetic etiology of human disease intersect with those of basic mechanisms in developmental biology, our… 
Highly Cited
1999
Highly Cited
1999
Expression of proneural and neurogenic genes in the embryonic mammalian vestibular system
One of the most striking aspects of all auditory and vestibular sensory epithelia is the mosaic pattern of hair cells and… 
Highly Cited
1997
Highly Cited
1997
JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial–mesenchymal interactions
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