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J 508

Known as: J-508 
National Institutes of Health

Papers overview

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2008
2008
[A comparison of the pharmacology of (-)-deprenyl to N-methylpropargylamine-1-aminoindane (J-508) and rasagiline, the desmethyl-analogue of J-508].
N-methylpropargylamine-1-aminoindane (J-508), a strong releaser of catecholamines was described 30 years ago as a more potent… 
Highly Cited
2005
Highly Cited
2005
The possible mechanisms of action of (-)deprenyl in Parkinson's disease
(-)Deprenyl, a selective inhibitor of MAO-B, was found to be 60 times less potent in inhibiting intestinal MAO in the rat than… 
2000
2000
Effect of MAO inhibitors on the high-affinity reuptake of biogenic amines in rat subcortical regions.
The noradrenaline (NA), dopamine (DA) and serotonin (5HT) reuptake inhibitory potency of deprenyl, the highly selective and… 
1982
1982
The aphrodisiac effect of low doses of (-) deprenyl in male rats.
The effects of single doses of (-)deprenyl, in comparison to J-508, U-1424, pargyline and clorgyline, on the sexual performance… 
1980
1980
Molecular characteristics of human platelet monoamine oxidase
SummaryThe monoamine oxidase B (MAO-B) selective inhibitor J-508 (N-methyl-N-propargyl-(1-indanyl)-ammonium chloride) appears to… 
1979
1979
The inhibition of rat brain monoamine oxidase-B by J-508 (N-methyl-N-propargyl-(1-indanyl)-ammonium hydrochloride), and its use for the titration of this enzyme form.
The interaction between rat brain monoamine oxidase-B and J-508, an analogue of L-deprenil, has been investigated. J-508 inhibits… 
1979
1979
Effects of selective monoamine oxidase (MAO) inhibitors on conditioned avoidance responses (CAR) of rats.
Dopamine (DA) insufficiency in the ipsilateral corpus striatum produced by unilateral electrolytic lesion of the substantia nigra… 
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