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Inhibitors of fatty acid amide hydrolase reduce carrageenan‐induced hind paw inflammation in pentobarbital‐treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
TLDR
In mice, treatment with indomethacin and URB597 produce SR144528‐sensitive anti‐inflammatory effects in the carrageenan model of acute inflammation, which is significantly lower than the corresponding activities in the noninflamed mice.
The palmitoylethanolamide family: a new class of anti-inflammatory agents?
TLDR
In the present review, the biochemical and pharmacological properties of PEA are discussed, in particular with respect to its analgesic and anti-inflammatory properties.
Transport of endocannabinoids across the plasma membrane and within the cell
TLDR
Anandamide uptake can be adequately described as a diffusion process across the plasma membrane followed by intracellular carrier‐mediated transport to effector molecules, catabolic enzymes and sequestration sites, although it is recognized that different cells are likely to utilize different mechanisms of endocannabinoid transport depending upon the utility of the endoc cannabinoidoid for the cell in question.
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
TLDR
The endocannabinoid system : drug targets, lead compounds, and potential therapeutic applications, and possible therapeutic applications.
Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide
TLDR
Palmitoylisopropylamide may prove useful as a template for design of compounds that reduce the cellular accumulation and metabolism of AEA without affecting either CB1 or CB2 receptors.
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
TLDR
The antiproliferative effects of the endocannabinoids upon C6 cells are brought about by a mechanism involving combined activation of both vanilloid receptors and to a lesser extent cannabinoid receptors, and leading to oxidative stress and calpain activation.
‘Entourage’ effects of N‐acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide‐induced vanilloid receptor activation and upon anandamide metabolism
TLDR
Although palmitoylethanolamide has entourage‐like effects at VR1 receptors expressed on hVR1‐HEK293 cells, other N‐acyl ethanolamines have even more dramatic potentiating effects and it is possible that they may play an important role under conditions where their synthesis is increased, such as in severe inflammation.
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2‐arachidonoylglycerol
TLDR
It is concluded that compounds like α‐Methyl‐1‐AG, O‐2203 and O-2204 may be useful as leads for the discovery of selective MAGL inhibitors that lack direct effects upon cannabinoid receptors.
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