B. Knoll

Publications74
h-index12
Citations586
Highly Influential Citations12
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Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer.
  • 112
  • 5
Phenylethylamine and tyramine are mixed-acting sympathomimetic amines in the brain.
On the helical strip of a capacitance vessel, the pulmonary artery of the rabbit, phenylethylamine (PEA) and tyramine act solely via displacement of noradrenaline from their storage sites and this… Expand
  • 56
  • 2
Differences in some behavioural effects of deprenyl and amphetamine enantiomers in rats
Effects of deprenyl and amphetamine enantiomers on different behavioural patterns were compared. Whereas (+)-amphetamine in doses of 1-3 mg/kg SC, (-)-amphetamine, and (+)-deprenyl in doses of 5-20… Expand
  • 15
  • 2
(−)1‐(Benzofuran‐2‐yl)‐2‐propylaminopentane, [(−)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain
The brain constituents β‐phenylethylamine (PEA) and tryptamine enhance the impulse propagation mediated transmitter release (exocytosis) from the catecholaminergic and serotoninergic neurons in the… Expand
  • 45
  • 1
Sexual hormones terminate in the rat: the significantly enhanced catecholaminergic/serotoninergic tone in the brain characteristic to the post-weaning period.
The amount of dopamine released from the striatum, substantia nigra and tuberculum olfactorium, noradrenaline from locus coeruleus and serotonin from the raphe, was significantly higher in four and… Expand
  • 37
  • 1
The effect of repeated administration of (-) deprenyl on the phenylethylamine-induced stereotypy in rats.
  • J. Tímár, B. Knoll
  • Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de…
  • 1986
Phenylethylamine (PEA) in a dose of 40 mg/kg induces a moderate and short-lasting stereotype behaviour. The intensity and duration of PEA-induced stereotypy was strongly potentiated in rats with… Expand
  • 11
  • 1
(-)Deprenyl and (-)1-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons.
The activity of the catecholaminergic neurons in the rat brain is enhanced significantly 30 min after the subcutaneous injection of very small doses of (-)deprenyl (threshold doses: 0.01 mg/kg for… Expand
  • 49
Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and…
The catecholaminergic and serotoninergic neurons in the brain change their performance according to the physiological need via a catecholaminergic/serotoninergic activity enhancer (CAE/SAE)… Expand
  • 34
The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant.
The peculiar tyramine uptake inhibitory effect of (-)deprenyl prompted structure-activity relationship studies aiming to develop new spectrum central nervous system stimulants which are devoid of MAO… Expand
  • 20
A pharmacological analysis elucidating why, in contrast to (-)-deprenyl (selegiline), alpha-tocopherol was ineffective in the DATATOP study.
The Parkinson Study Group who conducted the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial designed their study in the belief that the MAO inhibitor (-)-deprenyl… Expand
  • 15