Isocitrates

Known as: Isocitrates [Chemical/Ingredient], isocitrate 
Derivatives of isocitric acid, a structural isomer of CITRIC ACID, including its salts and esters.
National Institutes of Health

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2-nitroisocitrateisocitrateisocitric acidthreo-alpha-methylisocitrate
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Broader (1)

tricarboxylate

Papers overview

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Review
2017
Review
2017
Emerging therapies for acute myeloid leukemia
Acute myeloid leukemia (AML) is characterized by clinical and biological heterogeneity. Despite the advances in our understanding… (More)
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Highly Cited
2011
Highly Cited
2011
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the… (More)
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Highly Cited
2010
Highly Cited
2010
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in… (More)
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Highly Cited
2009
Highly Cited
2009
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… (More)
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Highly Cited
2009
Highly Cited
2009
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.
IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in… (More)
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Highly Cited
2005
Highly Cited
2005
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
Genes involved in fatty acid catabolism have undergone extensive duplication in the genus Mycobacterium, which includes the… (More)
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Highly Cited
2001
Highly Cited
2001
PLANT MITOCHONDRIA AND OXIDATIVE STRESS: Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species.
  • Ian M Moller
  • Annual review of plant physiology and plant…
  • 2001
The production of reactive oxygen species (ROS), such as O2- and H2O2, is an unavoidable consequence of aerobic metabolism. In… (More)
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Highly Cited
2000
Highly Cited
2000
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
Mycobacterium tuberculosis claims more human lives each year than any other bacterial pathogen. Infection is maintained in spite… (More)
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Highly Cited
1976
Highly Cited
1976
Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates.
1. The activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenase were measured in muscles from a… (More)
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Highly Cited
1974
Highly Cited
1974
Cardiac hypertrophy in spontaneously hypertensive rats.
Ventricular weight in spontaneously hypertensive rats (F26 generation, Okamoto-Aoki strain) was significantly higher (P < 0.001… (More)
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