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Iron-Regulatory Proteins

Known as: Iron Regulatory Protein, Iron Regulatory Factor, Iron Regulatory Proteins 
Proteins that regulate cellular and organismal iron homeostasis. They play an important biological role by maintaining iron levels that are adequate… 
National Institutes of Health

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IRPa protein, Plasmodium falciparumIron-Responsive Element Binding Proteins
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2006
Highly Cited
2006
Iron chelation in the biological activity of curcumin.
Highly Cited
1998
Highly Cited
1998
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.
Review
1998
Review
1998
Iron regulatory proteins, iron responsive elements and iron homeostasis.
The discovery of iron regulatory proteins (IRPs) has provided a molecular framework from which to more fully understand the… 
Highly Cited
1997
Highly Cited
1997
Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats.
Iron deficiency in young rats leads to a decrease in brain iron and ferritin concentrations, an increase in transferrin (Tf… 
Highly Cited
1995
Highly Cited
1995
Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome (*)
Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to specific structures, termed iron-responsive… 
Highly Cited
1994
Highly Cited
1994
Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs.
Translation of ferritin and erythroid 5‐aminolevulinate synthase (eALAS) mRNAs is regulated by iron via mRNA‐protein interactions… 
Highly Cited
1994
Highly Cited
1994
Iron regulates nitric oxide synthase activity by controlling nuclear transcription
Recently, it was reported that nitric oxide (NO) directly controls intracellular iron metabolism by activating iron regulatory… 
Highly Cited
1994
Highly Cited
1994
Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.
Iron regulatory factor (IRF) is a cytoplasmic mRNA-binding protein with specificity for iron-responsive element (IRE) RNA stem… 
Highly Cited
1993
Highly Cited
1993
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.
Biosynthesis of nitric oxide (NO) from L‐arginine modulates activity of iron‐dependent enzymes, including mitochondrial acontiase… 
Highly Cited
1993
Highly Cited
1993
Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.
Nitric oxide (NO) produced from L‐arginine by NO synthases (NOS) is a transmitter known to be involved in diverse biological… 
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