Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.

@article{Henderson1994OptimalSA,
  title={Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor.},
  author={Beric R. Henderson and E Menotti and Carine Bonnard and Lukas C. K{\"u}hn},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 26},
  pages={17481-9}
}
Iron regulatory factor (IRF) is a cytoplasmic mRNA-binding protein with specificity for iron-responsive element (IRE) RNA stem-loops. IRF post-transcriptionally regulates intracellular iron levels via binding to IREs in the untranslated regions of ferritin, transferrin receptor, and erythroid 5-aminolevulinic-acid synthase mRNAs. Specific IRE nucleotides… CONTINUE READING