Irinotecan hydrochloride

Known as: Camptothecin 11, camptothecin-11 (CPT-11) [brand name], CPT-11 
The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In… (More)
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Highly Cited
2004
Highly Cited
2004
Irinotecan hydrochloride (CPT-11) is a potent anticancer drug that is converted to its active metabolite, 7-ethyl-10… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. In a phase 2 study… (More)
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Highly Cited
2002
Highly Cited
2002
The metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically… (More)
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Highly Cited
2000
Highly Cited
2000
This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100… (More)
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Highly Cited
1999
Highly Cited
1999
TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their… (More)
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Highly Cited
1999
Highly Cited
1999
Programmed cell death (apoptosis) seems to be the principal mechanism whereby anti-oncogenic therapies such as chemotherapy and… (More)
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Highly Cited
1998
Highly Cited
1998
We have studied the apoptotic response of poly(ADP-ribose) polymerase (PARP)-/- cells to different inducers and the consequences… (More)
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Highly Cited
1996
Highly Cited
1996
Irinotecan hydrochloride (CPT-11), an antitumor camptothecin derivative, causes severe forms of diarrhea clinically. We… (More)
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Highly Cited
1994
Highly Cited
1994
A multi-institutional collaborative late phase II study of irinotecan hydrochloride (CPT-11) was performed on patients with… (More)
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